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CNDP2, also known as tissue carnosinase and peptidase A (EC 126.96.36.199), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]..
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These results provide evidence showing that intradimer interaction of H228 with the reaction center of the dimer counterpart is essential to the enzymatic activity of Cn2.
These findings suggest that the transduced PEP-1-PRX2 has neuroprotective functions against oxidative stress-induced (zeige SQSTM1 ELISA Kits) cell death in vitro and in vivo
Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 (zeige CNDP1 ELISA Kits) rs2346061, and CNDP1 (zeige CNDP1 ELISA Kits) rs2887) were overrepresented in power athletes compared with nonathletes.
These results suggest that the zinc form of CN2 is an active enzyme, but with a different substrate specificity from that of the manganese form.
To identify substrates of orphan transporter ATP-binding cassette subfamily C (zeige CYP ELISA Kits) member 5 (ABCC5 (zeige ABCC5 ELISA Kits)), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation.
Expression of CN2 in clinical colon tumors and colon cancer cell lines was significantly higher than that in normal colon mucosa cell lines. Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo.
Results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) (MAPK (zeige MAPK1 ELISA Kits)) pathway.
a key role of CNDP2 in PD neurodegeneration, by mechanisms that could involve oxidative stress, protein aggregation or inflammation.
deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer.
Common variants in CNDP1 (zeige CNDP1 ELISA Kits) and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes.
the crystal structure of the flop-selective allosteric modulator, PEPA, bound to the binding domains of the GluA2 (zeige GRIA2 ELISA Kits) and GluA3 (zeige GRIA3 ELISA Kits) flop isoforms of AMPA (zeige GRIA3 ELISA Kits) receptors
Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 (zeige CNDP1 ELISA Kits) genomic region and susceptibility for diabetic nephropathy in type 1 diabetes
Transgenic rice plants over-expressing the maize C4-pepc (zeige PEPCK ELISA Kits) gene encoding phosphoenolpyruvate carboxylase (zeige PEPCK ELISA Kits) (PC) and wild-type (WT) rice plants were subjected to PEG (zeige PAEP ELISA Kits) 6000 treatments to simulate drought stress. Compared with WT, PC had the higher survival rate and net photosynthetic rate after 16days of drought treatment, and had higher relative water content in leaves after 2h of drought treatment as well.
PEPC (zeige PEPCK ELISA Kits) can improve both stress tolerance and grain yield in wheat.
CNDP2, also known as tissue carnosinase and peptidase A (EC 188.8.131.52), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003
cytosolic non-specific dipeptidase
, cytosolic nonspecific dipeptidase 2
, cytosolic nonspecific dipeptidase
, glutamate carboxypeptidase-like protein 1
, peptidase 1
, peptidase A
, CNDP dipeptidase 2
, CNDP dipeptidase 2 (metallopeptidase M20 family)
, CNDP dipeptidase 2 b
, CNDP dipeptidase 2 (metallopeptidase M20 family) b
, CNDP dipeptidase 2 a
, P-pyruvate carboxylase
, PEP carboxylase
, PEPCase 1
, phosphoenolpyruvate carboxylase 1