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The protein encoded by CLRN1-AS1 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta.
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Extracellular ISG15 (zeige ISG15 ELISA Kits) signals cytokine secretion through the LFA-1 (zeige ITGAL ELISA Kits) integrin receptor (CD11a (zeige ITGAL ELISA Kits)/CD18 (zeige ITGB2 ELISA Kits)) in natural killer cells.
results demonstrate that ISG15 (zeige ISG15 ELISA Kits) governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent.
Loss of ISG15 (zeige ISG15 ELISA Kits) expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice
ISG15 (zeige ISG15 ELISA Kits) acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.
USP18 (zeige USP18 ELISA Kits)'s ISG15 (zeige ISG15 ELISA Kits) specificity is mediated by a small interaction interface.
Posttranslational protein modification by ISG15 (zeige ISG15 ELISA Kits) plays an important role in antiviral defense
These studies provide evidence, ISG15 (zeige ISG15 ELISA Kits) is elevated following TBI in mice, preceding MLCK (zeige MYLK ELISA Kits) elevation, development of BBB (zeige ALMS1 ELISA Kits) disruption, and cerebral edema.
Kruppel-like factor 9 (KLF9) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.
Propose that Isg15 (zeige ISG15 ELISA Kits)-dependent degradation of p53 (zeige TP53 ELISA Kits) represents an alternative mechanism of controlling p53 (zeige TP53 ELISA Kits) protein levels, and, thus, it is an attractive pathway for drug discovery.
Embryo mortality occurs in pregnant Isg15 (zeige ISG15 ELISA Kits)(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.
ISG15 (zeige ISG15 ELISA Kits) is able to trigger IFN-gamma (zeige IFNG ELISA Kits) production and other signaling pathways suggesting it is a potential cytokine that could interact with still unknown receptors. (Review)
ISG15 (zeige ISG15 ELISA Kits) induces cancer cell apoptosis by disrupting the NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathway. This study highlighted a novel role of ISG15 (zeige ISG15 ELISA Kits) in tumor suppression.
The Interferon (zeige IFNA ELISA Kits)-stimulated 15-KDa protein (ISG15 (zeige ISG15 ELISA Kits)) rs1921 variant and ISG15 (zeige ISG15 ELISA Kits) expression are associated with HBV-related liver diseases.
findings revealed that MERS-CoV PLpro chiefly engages human ISG15 (zeige ISG15 ELISA Kits) through its C-terminal domain; structure of MERS-CoV PLpro was solved to 2.4 A in complex with the C-terminal domain of hISG15; structure of MERS-CoV PLpro in complex with this domain exposed the interface between these two entities
Our study demonstrates a protumor role of ISG15 (zeige ISG15 ELISA Kits), and suggests that ISG15 (zeige ISG15 ELISA Kits) is a prognostic predictor and a potential therapeutic target for nasopharyngeal carcinoma
Results show that HERC5 mediates covalent ISG15 conjugation to parkin in mammalian cells and that ISG15 is conjugated to the Lys349 and Lys369 residues of parkin which increases its ubiquitin E3 ligase activity.
Results suggest that unconjugated ISG15 (zeige ISG15 ELISA Kits) affects the functions of HCV NS5A through protein-protein interaction.
This report demonstrates that ISG15 (zeige ISG15 ELISA Kits) induced by Hepatitis E virus replication in Huh7-S10 (zeige L1CAM ELISA Kits)-3 human liver cells plays an immunomodulatory role by negatively regulating type I Interferon (zeige IFNA ELISA Kits) signaling and, thus, Hepatitis E virus sensitivity to type I Interferon (zeige IFNA ELISA Kits).
epletion of either ISG15 or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux.
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
ubiquitin-like protein ISG15
, interferon-stimulated protein 15
, ubiquitin cross-reactive protein
, interferon-induced 15 kDa protein
, interferon-induced 15-KDa protein
, interferon-induced 17 kDa protein
, interferon, alpha-inducible protein
, interferon-stimulated protein (15 kDa)
, interferon, alpha-inducible protein (clone IFI-15K)
, interferon-induced 17-kDa/15-kDa protein
, interferon-stimulated protein, 15 kDa