CKLF-Like MARVEL Transmembrane Domain Containing 8 Proteine (CMTM8)

CMTM8 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. Zusätzlich bieten wir Ihnen CMTM8 Antikörper (32) und CMTM8 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CMTM8 152189 Q8IZV2
CMTM8 70031 Q9CZR4
Ratte CMTM8 CMTM8 301045  
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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CMTM8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu CKLF-Like MARVEL Transmembrane Domain Containing 8 (CMTM8) Interaktionspartnern

Human CKLF-Like MARVEL Transmembrane Domain Containing 8 (CMTM8) Interaktionspartner

  1. This is the first extensive study of CMTM8 expression in both normal and tumorous human tissues. Our findings strongly supported the potential role of CMTM8 as a novel tumor suppressor and may shape further functional studies on this gene

  2. our data suggested that CMTM8 is an important tumor suppressor gene in human bladder cancer and qualified as a useful prognostic indicator for patients with bladder cancer.

  3. overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer.

  4. This study identified CMTM8 as a new candidate tumor suppressor gene and GPR177 (zeige WLS Proteine) as a new candidate oncogene (zeige RAB1A Proteine) in osteosarcoma.

  5. Down-regulation of CMTM8 also promoted an epithelial mesenchymal transition-like change in MCF-10A cells, indicating a broader role for CMTM8 in regulating cellular transformation.

  6. Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (zeige CMTM1 Proteine)-8 gene clusters, between the SCY and the TM4SF (zeige TSPAN1 Proteine) gene families. The 8 family members were cloned and characterized.

  7. These results identify CKLFSF8 as a novel regulator of EGF (zeige EGF Proteine)-induced signaling and indicate that the association of EGFR (zeige EGFR Proteine) with four transmembrane proteins is critical for EGFR (zeige EGFR Proteine) desensitization.

  8. Cell proliferation and expression of EGFR (zeige EGFR Proteine) of tumor cells can be inhibited by transfection of CKLFSF8.

  9. These data implicate CMTM8 as a negative regulator of epidermal growth factor (EGF (zeige EGF Proteine))-induced signaling.

  10. The cloning and sequencing of an alternative splice form of CMTM8, obtained from a human blood cDNA library, that utilizes apoptotic pathways distinct from CMTM8, is reported.

CMTM8 Protein Überblick

Protein Überblick

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.

Genbezeichner und Symbole assoziert mit CMTM8

  • CKLF-like MARVEL transmembrane domain containing 8 L homeolog (cmtm8.L)
  • CKLF like MARVEL transmembrane domain containing 8 (CMTM8)
  • CKLF-like MARVEL transmembrane domain containing 8 (cmtm8)
  • CKLF-like MARVEL transmembrane domain containing 8 (Cmtm8)
  • 2700018N07Rik Protein
  • AA408515 Protein
  • Cklfsf8 Protein
  • CKLFSF8-V2 Protein
  • marveld1 Protein
  • MGC82744 Protein

Bezeichner auf Proteinebene für CMTM8

MARVEL domain-containing protein 1 , CKLF-like MARVEL transmembrane domain containing 8 , CKLF-like MARVEL transmembrane domain-containing protein 8 , chemokine-like factor super family 8 , chemokine-like factor superfamily 8 , chemokine-like factor superfamily member 8 , chemokine-like related protein 8

GENE ID SPEZIES
444070 Xenopus laevis
460249 Pan troglodytes
704234 Macaca mulatta
100380017 Xenopus (Silurana) tropicalis
152189 Homo sapiens
485625 Canis lupus familiaris
533671 Bos taurus
70031 Mus musculus
301045 Rattus norvegicus
420665 Gallus gallus
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