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The protein encoded by CD151 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
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in complex with P2Y12 (zeige P2RY12 ELISA Kits) receptor contributes to thrombus growth and stability
Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI (zeige FCER1A ELISA Kits)-Mediated Mast Cell Activation
Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program.
Study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes.
We identify CD151 as a critical factor in tetradecanoylphorbol acetate-dependent skin carcinogenesis.
Loss of CD151 is associated with drug sensitivity in skin squamous cell carcinoma.
study provides strong evidence that CD151 collaborates with LB integrins (particularly alpha6beta4 and ErbB2 (zeige ERBB2 ELISA Kits) (and EGFR (zeige EGFR ELISA Kits)) receptors to regulate multiple signaling pathways, thereby driving mammary tumor onset, survival, and metastasis
CD151 importantly modulates podocyte function.
establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy
CD151 maintains vascular stability by promoting endothelial cell adhesions, especially cell-cell adhesion, and confining cytoskeletal tension.
We conclude that LAMC1 (zeige LAMC1 ELISA Kits) mRNA acts as a trans regulator to stimulate CD151 expression by competing for miR (zeige MLXIP ELISA Kits)-124 binding in hepatocellular carcinoma cells.
CD151 overexpression was associated with poor survival in human solid tumors. CD151 could be a valuable prognosis biomarker or a potential therapeutic target of solid tumors.
Levels of CD151 Gene Expression are Independently Associated with Survival in Chemoradiotherapy-Naive Patients
CD151 induces osteosarcoma metastasis likely by regulating cell function through adhesion signaling
These results elucidated that PIK3C2A (zeige PIK3C2A ELISA Kits) mRNA acts as a miR (zeige MLXIP ELISA Kits)-124 decoy to regulate CD151 and to affect hepatocellular carcinoma malignant phenotypes.
the tetraspanin CD151 contributes to survival of a subset of high-grade serous ovarian cancer cell lines.
CD151 in humans thus marks and enables hyperproliferative T cells.
Here, we demonstrate for the first time that the tetraspanin CD151 supports lymphocyte adhesion to liver endothelium. We show that CD151 is upregulated in chronic liver disease and hepatocellular carcinoma (HCC) and is regulated on endothelium by tissue remodeling and procarcinogenic factors.
Our data uncover a previously unknown mechanism for modulating human airway smooth muscle contraction, implicating CD151 as a determinant of airway hyper-responsiveness in vivo, likely through regulation of G protein-coupled receptor (zeige ADRA1A ELISA Kits)-induced calcium mobilization and protein kinase c (zeige PKC ELISA Kits) signaling
Reciprocal fusion gene involving TSPAN4-CD151 is associated with infratentorial anaplastic ependymoma.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
CD151 molecule (Raph blood group)
, CD151 antigen
, membrane glycoprotein SFA-1
, platelet-endothelial tetraspan antigen 3
, CD151 antigen (Raph blood group)
, hemidesmosomal tetraspanin CD151
, platelet surface glycoprotein gp27
, platelet-endothelial cell tetraspan antigen 3
, platelet endothelial tetraspan antigen-3
, RNA binding protein CD151