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CNBP encodes a nucleic-acid binding protein with seven zinc-finger domains. Zusätzlich bieten wir Ihnen CNBP Antikörper (105) und CNBP Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human CNBP Protein expressed in Wheat germ - ABIN1349806
Raheem, Olufemi, Bachinski, Vihola, Sirito, Holmlund-Hampf, Haapasalo, Li, Udd, Krahe: Mutant (CCTG)n expansion causes abnormal expression of zinc finger protein 9 (ZNF9) in myotonic dystrophy type 2. in The American journal of pathology 2010
The authors report a previously unknown long noncoding RNA which, together with CNBP, is involved in the fine-tuned regulation of CCND1 (zeige CCND1 Proteine) mRNA stability, without which CCND1 (zeige CCND1 Proteine) exhibits, at most, partial expression.
[CCTG (zeige CCT3 Proteine)]n repeat expansion, differently from the DM1 (zeige DMPK Proteine) mutation, does not influence the methylation status of the CNBP gene and other molecular mechanisms are involved in the pathogenesis of Myotonic Dystrophy type 2..
RNA sequence preferences of unconventional RNA-binding proteins, Nudt21 (zeige NUDT21 Proteine) and CNBP, has been described.
A second point is that DM mutations, although located in noncoding regions, may reduce the expression of mutant alleles, raising questions whether loss-of-function may contribute to the phenotype, or possibly impose a safety limit on knockdown therapies that create or aggravate a DMPK (zeige DMPK Proteine) or CNBP deficiency state
CNBP is supporting translation by resolving stable structures on mRNAs.
A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage.
The cnbp overexpression rescued the Treacher Collins Syndrome phenotype in a dose-dependent manner by a reactive oxygen species-cytoprotective action that prevented the redox-responsive genes' upregulation but did not normalize the synthesis of ribosomal RNAs.
High CNBP expression is associated with Medulloblastoma.
CNBP overexpression caused increase of cell death and suppression of cell metastasis through its induction of G-quadruplex formation in the promoter of hnRNP K (zeige HNRNPK Proteine) resulting in hnRNP K (zeige HNRNPK Proteine) down-regulation
Arginine methylation of CNBP in the RG motif does not change the subcellular localization but regulates its RNA binding activity.
data support a role for CNBP as a critical transcription factor and a key regulator of the prolonged expression of sustained cytokine IL-6 (zeige IL6 Proteine) during persistent LPS (zeige TLR4 Proteine) stimulation or Gram-negative bacterial infection
CNBP up-regulates tbx2b and smarca5 (zeige SMARCA5 Proteine), and down-regulates wnt5b (zeige WNT5B Proteine) gene expression.
expression of APP (zeige APP Proteine)(Swe) in murine tissue induces a decrease in CNBP expression.
CNBP targets Myc (zeige MYC Proteine) in rostral head formation, is essential for forebrain induction and specification.
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
cellular nucleic acid-binding protein
, zinc finger protein 9
, cellular nucleic acid binding protein
, erythroid differentiation-related
, sterol regulatory element-binding protein
, zinc finger protein 273
, zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
, cellular nucleic acid binding protein 1
, cellular nucleic acid binding protein a
, DNA binding protein