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CNBP encodes a nucleic-acid binding protein with seven zinc-finger domains.
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[CCTG]n repeat expansion, differently from the DM1 (zeige DMPK ELISA Kits) mutation, does not influence the methylation status of the CNBP gene and other molecular mechanisms are involved in the pathogenesis of Myotonic Dystrophy type 2..
RNA sequence preferences of unconventional RNA-binding proteins, Nudt21 (zeige NUDT21 ELISA Kits) and CNBP, has been described.
A second point is that DM mutations, although located in noncoding regions, may reduce the expression of mutant alleles, raising questions whether loss-of-function may contribute to the phenotype, or possibly impose a safety limit on knockdown therapies that create or aggravate a DMPK (zeige DMPK ELISA Kits) or CNBP deficiency state
CNBP is supporting translation by resolving stable structures on mRNAs.
A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage.
The cnbp overexpression rescued the Treacher Collins Syndrome phenotype in a dose-dependent manner by a reactive oxygen species-cytoprotective action that prevented the redox-responsive genes' upregulation but did not normalize the synthesis of ribosomal RNAs.
High CNBP expression is associated with Medulloblastoma.
CNBP overexpression caused increase of cell death and suppression of cell metastasis through its induction of G-quadruplex formation in the promoter of hnRNP K (zeige HNRNPK ELISA Kits) resulting in hnRNP K (zeige HNRNPK ELISA Kits) down-regulation
Arginine methylation of CNBP in the RG motif does not change the subcellular localization but regulates its RNA binding activity.
CNBP are novel antigens for SLE patients and the recognition of CNBP might be differentiated dependent on the level of arginine methylation.
data support a role for CNBP as a critical transcription factor and a key regulator of the prolonged expression of sustained cytokine IL-6 during persistent LPS stimulation or Gram-negative bacterial infection
CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b (zeige WNT5B ELISA Kits) gene expression.
expression of APP (zeige APP ELISA Kits)(Swe) in murine tissue induces a decrease in CNBP expression.
CNBP targets Myc (zeige MYC ELISA Kits) in rostral head formation, is essential for forebrain induction and specification.
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
cellular nucleic acid-binding protein
, zinc finger protein 9
, cellular nucleic acid binding protein
, erythroid differentiation-related
, sterol regulatory element-binding protein
, zinc finger protein 273
, zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
, cellular nucleic acid binding protein 1
, cellular nucleic acid binding protein a
, DNA binding protein