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Binds high-mannose carbohydrates in a Ca(2+)-dependent manner.
Showing 10 out of 157 products:
Human Polyclonal CLEC6A Primary Antibody für IHC (fro), IHC (p) - ABIN315995
Brasch, Mörig, Neumann, Proksch: Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor. in Mycoses 2014
Human Monoclonal CLEC6A Primary Antibody für CyTOF, FACS - ABIN4900356
Gringhuis, Wevers, Kaptein, van Capel, Theelen, Boekhout, de Jong, Geijtenbeek: Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. in PLoS pathogens 2011
Human Monoclonal CLEC6A Primary Antibody für FACS - ABIN4897579
Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. in Journal of leukocyte biology 2017
Dectin-2 is a primary factor in activation of NLRP3 (zeige NLRP3 Antikörper) inflammasome during Histoplasma capsulatum infection.
this report relates the potential of the Dectin-2/Card9 (zeige CARD9 Antikörper)-coupled pathway in ocular autoimmunity. Not only does it contribute to understanding of how innate immune receptors orchestrate T cell-mediated autoimmunity, it also reveals a previously unappreciated ability of fungal-derived signals to promote autoimmunity.
a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells
Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.
activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk (zeige SYK Antikörper)-dependent manner.
this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance
these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (zeige TLR4 Antikörper) responses through interaction with Dectin-2.
Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 (zeige HAND1 Antikörper) differentiation.
this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis
The results indicate differential roles for Dectin-2 and Mincle (zeige CLEC4E Antikörper) in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.
Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin (zeige MBL2 Antikörper) domain containing 6A)
This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis.
human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2
our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.
The Dectin-2 possess a single extracellular conserved C-type lectin (zeige MBL2 Antikörper)-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.
Thus, dectin-1 (zeige CLEC7A Antikörper) and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1 (zeige MALT1 Antikörper)-dependent activation of c-Rel (zeige NFkBP65 Antikörper).
human DECTIN-2 has a role in innate immunity
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
C-type lectin domain family 6, member A
, C-type lectin domain family 6 member A
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10
, C-type lectin superfamily member 10
, DC-associated C-type lectin 2
, dendritic cell-associated C-type lectin 2
, natural killer complex lectin
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
, dectin 2