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CLEC4M encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver.
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heterozygous VNTR genotypes 57 and 67 of CLEC4M were highly enriched and are the most likely mechanism through which CLEC4M contributes to disease in the Swedish type 1 VWD (zeige VWF ELISA Kits) population
DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A (zeige STAT5A ELISA Kits). And HNRNPKP2 decreased the expression of downstream target gene CXCR4 (zeige CXCR4 ELISA Kits). These findings indicated potential therapeutic candidates for gastric cancer liver metastasis.
the neck domains of DC-SIGN (zeige CD209 ELISA Kits) and DC-SIGNR can contribute to the different functions of these receptors by presenting the sugar-binding sites in different contexts.
Together, these studies confirm a role for C-type lectin (zeige MBL2 ELISA Kits) receptors DC-SIGN (zeige CD209 ELISA Kits) and L-SIGN as attachment factors and entry receptors for human metapneumovirus infection.
DC-SIGNR VNTR and DC-SIGN (zeige CD209 ELISA Kits) VNTR were not associated with the risk of pulmonary tuberculosis in a sample of Iranian population
CD209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression.
DC-SIGNR expression in peripheral blood mononuclear cells was higher in HIV-1-infected patients, and its positive correlation with viral load and negative with CD4 (zeige CD4 ELISA Kits)+ T cells counts suggest a potential role of DC-SIGNR in HIV-1 infection.
Study demonstrated that serum levels of DC-SIGNR in lung cancer patients were significantly lower than those in healthy individuals, and correlated significantly with brain metastasis and serum NK cells percentage.
Genetic variations in STXBP5 and CLEC4M are associated with VWF (zeige VWF ELISA Kits) level variation in type 1, but not in type 2 von Willebrand disease.
of an association between CD209 (zeige CD209 ELISA Kits) and CD209L polymorphisms and tuberculosis development in a Brazilian population
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
C-type lectin domain family 4 member M
, CD209 antigen-like protein 1
, CD299 antigen
, DC-SIGN-related protein
, dendritic cell-specific ICAM-3-grabbing non-integrin 2
, liver/lymph node-specific ICAM-3 grabbing non-integrin
, liver/lymph node-specific ICAM-3-grabbing non-integrin
, mannose binding C-type lectin DC-SIGNR
, CD209b antigen