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BUB1B encodes a kinase involved in spindle checkpoint function.
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Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (zeige CDC20 ELISA Kits)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (zeige MYO5A ELISA Kits) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 by BUB1 is dispensable for SAC (zeige ADCY10 ELISA Kits) activation
Up-regulation of desmocollin-1 (DSC1 (zeige DSC1 ELISA Kits)) was observed in wild-type, but not Low-budding uninhibited by benzimidazole-related 1(BubR1)-expressing mutant (BubR1(L/L)) mice after partial hepatectomy (PHx).
The combination of budding uninhibited by benzimidazole-related 1 (BUBR1) insufficiency and administration of KBrO3 worsens the proliferative capacity compared with the impaired proliferation induced by BUBR1 insufficiency alone.
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (zeige EZH2 ELISA Kits) directly interacted with and stabilized BubR1, an effect driving EZH2 (zeige EZH2 ELISA Kits) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1 (zeige ERCC1 ELISA Kits)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (zeige ERCC1 ELISA Kits)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (zeige SGOL1 ELISA Kits) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
Together, our findings demonstrate that Bub1 acts at multiple points to assure the correct kinetochore formation.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
MAD3/BUB1-related protein kinase
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint kinase MAD3L
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog, beta
, BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like