anti-Bridging Integrator 1 (BIN1) Antikörper

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Zusätzlich bieten wir Ihnen BIN1 Kits (14) und BIN1 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BIN1 274 O00499
BIN1 30948 O08539
BIN1 117028 O08839
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Top anti-BIN1 Antikörper auf antikoerper-online.de

Showing 10 out of 120 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA, WB Western Blot of Mouse Anti-BIN-1 Antibody. Lane 1: LNCap. Lane 2: WM1341D. Lane 3: WM164. Lane 4: WM983A. Lane 5: WM793. Lane 6: WM239A. Lane 7: WM35. Load: 35 µg per lane. Primary antibody: BIN-1 antibody (Exon 12A specific) at 1:400 for overnight at 4°C. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$389.00
Details
Maus Maus Unkonjugiert FACS, IP, IHC, ELISA, WB Western Blot of Anti-BIN1 Antibody. Lane 1: Keratinocyte derived from Bin1 wild type mice. Lane 2: Keratinocyte derived from Bin1 null mice. Load: 35 µg per lane. Primary antibody: BIN1 monoclonal Antibody. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 1xPBS, 0.4% Tween-20. Other band(s): non-specific. 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$389.00
Details
Maus Maus Unkonjugiert IP, IHC, ELISA, WB Immunohistochemistry of Mouse Anti-BIN1 antibody. Tissue: skeletal muscle from BIN-1 wild type (+/+) and null (-/-) mouse. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: BIN-1 antibody for 1hr at RT. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: BIN1 is nuclear and cytoplasmic. Staining: BIN1 as precipitated brown signal. 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$389.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Bin1 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Mouse Pancreas 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Maus Maus Unkonjugiert IP, ELISA, WB Immunofluorescence Microscopy of Mouse Anti-BIN1 Antibody. Cells: C2C12 cells during growth or differentiation. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: BIN-1 (Exon 10 specific, 99F) monoclonal antibody. Secondary antibody: mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: BIN1 is nuclear and cytoplasmic. Staining: BIN 1 as green fluorescent signal. 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$389.00
Details
Human Maus Unkonjugiert WB BIN1 monoclonal antibody (M01), clone 1H1 Western Blot analysis of BIN1 expression in HeLa NE. Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN334360 (0.1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Maus Unkonjugiert ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using BIN1 mAb against human BIN1 (AA: 189-398) recombinant protein. (Expected MW is 47.1 kDa) 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$561.00
Details
Human Maus Unkonjugiert ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using BIN1 mAb against human BIN1 (AA: 189-398) recombinant protein. (Expected MW is 47.1 kDa) 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$561.00
Details

BIN1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-BIN1 Antikörper

  1. Chicken Monoclonal BIN1 Primary Antibody für IF, IHC (p) - ABIN533202 : Negorev, Riethman, Wechsler-Reya, Sakamuro, Prendergast, Simon: The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. in Genomics 1997 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Monoclonal BIN1 Primary Antibody für FACS, IP - ABIN1043735 : Nicot, Toussaint, Tosch, Kretz, Wallgren-Pettersson, Iwarsson, Kingston, Garnier, Biancalana, Oldfors, Mandel, Laporte: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. in Nature genetics 2007 (PubMed)

  3. Mouse (Murine) Monoclonal BIN1 Primary Antibody für IP, ELISA - ABIN1043737 : Wechsler-Reya, Elliott, Prendergast: A role for the putative tumor suppressor Bin1 in muscle cell differentiation. in Molecular and cellular biology 1998 (PubMed)

  4. Human Monoclonal BIN1 Primary Antibody für ELISA, WB - ABIN1043789 : Wechsler-Reya, Sakamuro, Zhang, Duhadaway, Prendergast: Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. in The Journal of biological chemistry 1998 (PubMed)

  5. Human Polyclonal BIN1 Primary Antibody für ICC, IF - ABIN4284657 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

Weitere Antikörper gegen BIN1 Interaktionspartner

Human Bridging Integrator 1 (BIN1) Interaktionspartner

  1. The findings reveal the ability of Bin1 to modify actin dynamics and provide a possible mechanistic connection between Bin1 and tau-induced pathobiological changes of the actin cytoskeleton.

  2. the association between the rs744373 polymorphism of BIN1 protein and late-onset Alzheimer's disease in East Asian, American, and European populations (Meta-Analysis)

  3. Italian family with centronuclear myopathy, carrying a novel pathogenic mutation of BIN1 gene in heterozygous state, consistent with autosomal dominant inheritance.

  4. bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations

  5. Findings indicated that BIN1 restoration in NSCLC could reverse PD-L1 (zeige CD274 Antikörper)-mediated immune escape by inactivating the c-MYC (zeige MYC Antikörper) and EGFR (zeige EGFR Antikörper)/mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathways.

  6. propose that efforts to define how genetic variants in BIN1 elevate the risk for Alzheimer's disease would behoove to consider BIN1 function in the context of its main expression in mature oligodendrocytes

  7. The results emphasize an additional level of complexity in the regulation of the interaction between BIN1 and Tau dependent on the BIN1 isoforms.

  8. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (zeige CHMP4A Antikörper) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (zeige CHMP4A Antikörper) = charged multivesicular body protein 4B (zeige CHMP4B Antikörper); cBIN1 = cardiac bridging integrator 1)

  9. Low Bin1 expression is associated with esophageal squamous cell carcinoma.

  10. the depletion of BIN1 increases cellular BACE1 (zeige BACE Antikörper) levels through impaired endosomal trafficking and reduces BACE1 (zeige BACE Antikörper) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (zeige BACE Antikörper) levels and Ab production

Mouse (Murine) Bridging Integrator 1 (BIN1) Interaktionspartner

  1. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (zeige CHMP4B Antikörper) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (zeige CHMP4B Antikörper) = charged multivesicular body protein 4B (zeige CHMP4B Antikörper); cBIN1 = cardiac bridging integrator 1)

  2. Bin1 and CD2AP (zeige Cd2ap Antikörper) keep APP (zeige APP Antikörper) and BACE1 (zeige BACE Antikörper) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (zeige APP Antikörper) in neurons increasing the risk for late-onset AD.

  3. the depletion of BIN1 increases cellular BACE1 (zeige BACE Antikörper) levels through impaired endosomal trafficking and reduces BACE1 (zeige BACE Antikörper) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (zeige BACE Antikörper) levels and Ab production

  4. Data demonstrate that EHBP1L1 links Rab8 (zeige RAB8A Antikörper) and the Bin1-dynamin (zeige DNM1 Antikörper) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  5. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.

  6. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.

  7. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.

  8. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (zeige E2F1 Antikörper) is a mechanism by which serum starvation promotes E2F1 (zeige E2F1 Antikörper)-induced apoptosis.

  9. BIN1 interacts with MTM1 (zeige MTM1 Antikörper) in skeletal muscle.

  10. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

Pig (Porcine) Bridging Integrator 1 (BIN1) Interaktionspartner

  1. Report remodeling of the t-t nano-architecture in the post-MI heart that extends to the remote region and dysregulation of junctophilin-2 (zeige JPH2 Antikörper) and bridging integrator 1.

BIN1 Antigen-Profil

Protein Überblick

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Genbezeichner und Symbole assoziert mit BIN1

  • bridging integrator 1 (BIN1) Antikörper
  • bridging integrator 1 S homeolog (bin1.S) Antikörper
  • bridging integrator 1 (bin1) Antikörper
  • bridging integrator 1b (bin1b) Antikörper
  • bridging integrator 1 (Bin1) Antikörper
  • ALP-1 Antikörper
  • AMPH2 Antikörper
  • Amphl Antikörper
  • BIN1 Antikörper
  • BRAMP-2 Antikörper
  • cb57 Antikörper
  • MGC53185 Antikörper
  • MGC76187 Antikörper
  • SH3P9 Antikörper
  • zgc:86701 Antikörper

Bezeichner auf Proteinebene für BIN1

bridging integrator 1 , myc box-dependent-interacting protein 1-like , amphiphysin II , amphiphysin-like protein , box dependant MYC interacting protein 1 , box-dependent myc-interacting protein 1 , myc box-dependent-interacting protein 1 , SH3 domain-containing protein 9 , amphiphysin 2 , myc box dependent interacting protein 1 , Amph2 , amphiphysin IIamph2

GENE ID SPEZIES
100052213 Equus caballus
380484 Xenopus laevis
394839 Xenopus (Silurana) tropicalis
447863 Danio rerio
735972 Pan troglodytes
100451162 Pongo abelii
100475668 Ailuropoda melanoleuca
100018912 Monodelphis domestica
100544136 Meleagris gallopavo
100599872 Nomascus leucogenys
274 Homo sapiens
30948 Mus musculus
424228 Gallus gallus
100037305 Sus scrofa
117028 Rattus norvegicus
483870 Canis lupus familiaris
614576 Bos taurus
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