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Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution\; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. Zusätzlich bieten wir Ihnen BLMH Antikörper (98) und BLMH Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.
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Blmh interacts with diverse cellular processes--lipoprotein, amino acid and protein, carbohydrate, and energy metabolisms, detoxification, antioxidant defenses--that are essential for normal kidney homeostasis.
Bleomycin hydrolase protects against neurodegeneration associated with elevated homocysteine thiolactone levels in hyperhomocysteinemia and Alzheimer's disease.
bleomycin hydrolase functions as an MHC class I epitope-processing protease
BH does not play a major role either in generating or destroying class I major histocompatibility antigen (MHC)-presented peptides that bind to the MHC in living cells. These results point to redundant functions between peptidases.
the BLMH gene single nucleotide polymorphism A1450G (rs1050565) influences BLMH activity and late pulmonary toxicity.
Ubc9 (zeige UBE2I ELISA Kits) plays different roles of action in antitumor agents in chemotherapy. The process requires bleomycin hydrolase and poly(ADP-ribose) polymerase-1 (zeige PARP1 ELISA Kits). The results are beneficial to deeply understanding of Ubc9 (zeige UBE2I ELISA Kits) functions and for precise prediction of chemotherapy outcomes in tumors.
Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of filaggrin (zeige FLG ELISA Kits) gene mutations
This study findings suggest that Blmh interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis.
We also detected significant association between XRCC1, XRCC3, and BLHX polymorphisms and a high frequency of chromosomal damage
The caspase (zeige CASP3 ELISA Kits)-dependent cleavage of BLH was confirmed by cleavage of partly-purified human bleomycin hydrolase with caspase-3 (zeige CASP3 ELISA Kits).
present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC
This first report on BLMH carrier status in Tunisia shows o association between carrying the BLMH-G genotype and Alzheimer's disease in epsilon4 negative or positive subjects.
Cysteine proteases bleomycin hydrolase and cathepsin Z (zeige CTSZ ELISA Kits) mediate N-terminal proteolysis and toxicity of mutant huntingtin (zeige HTT ELISA Kits).
BH activity and expression were markedly decreased in AD lesional skin, suggesting a defect of the filaggrin (zeige FLG ELISA Kits) degradation pathway in AD.
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution\; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
, bleomycin hydrolase
, BLM hydrolase
, aminopeptidase H