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BICC1 encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Zusätzlich bieten wir Ihnen BICC1 Antikörper (55) und BICC1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
These results demonstrate that the function of Bicc1 in the kidney is evolutionarily conserved, thus supporting the use of zebrafish as an alternative in vivo model to study the role of mammalian Bicc1 in renal cyst formation.
genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population.
Our findings suggested rs17648524 (intronic RBFOX1 gene) and rs7084402 (7.5kb 5' of the BICC1 gene) showed gender-specific associations with high myopia in the Han Chinese.
Suggest allelic changes in the regulation of the BICC1 gene in amygdala neurones may contribute to mood disorders.
Results provide some support for the involvement of BICC1 and PCLO (zeige PCLO ELISA Kits) in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes
findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior
Polymorphisms in intron 2 of BICC1 are associated with its expression and bone (zeige BEST1 ELISA Kits) mineral density (BMD)
The minor T-allele of BICC1 has a protective role against major depressive disorder and its known structural and functional brain changes.
The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt (zeige WNT2 ELISA Kits) inhibitory activity. The point mutation in the SAM (zeige TTN ELISA Kits) domain results in a 22% loss of activity.
Polymerization is a novel disease-relevant mechanism both to stabilize Bicc1 and to present associated mRNAs in specific silencing platforms.
discovered that loss of the Pkd1 (zeige PKD1 ELISA Kits) gene product, polycystin-1 (PC1 (zeige PKD1 ELISA Kits)), whose mutation causes human autosomal dominant polycystic kidney disease (ADPKD), downregulates Bicc1 expression in vitro and in vivo
Bicc1 is a novel regulator of osteoblastogenesis and bone mineral density (BMD (zeige BEST1 ELISA Kits))
Bicc1 KH domains bind the 3' UTRs of AC6 (zeige ADCY6 ELISA Kits) and PKIa (zeige PKIA ELISA Kits) mRNAs and cognate miRNA precursors, whereas the SAM (zeige TTN ELISA Kits) domain loads a silencing complex with AGO2 (zeige EIF2C2 ELISA Kits). AC6 (zeige ADCY6 ELISA Kits) and PKIa (zeige PKIA ELISA Kits) protein levels increase in cystic Bicc1-/- mouse kidneys.
lack of Bicc1 leads to disruption of normal cell-cell junctions.
Data suggest that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2 (zeige PKD2 ELISA Kits) by antagonizing the repressive activity of the miR-17 microRNA family on the 3'UTR (zeige UTS2R ELISA Kits) of Pkd2 (zeige PKD2 ELISA Kits) mRNA.
Binds homoribopolymers in vitro; the third K homology domain is necessary and sufficient for in vitro Bicc1 RNA binding.
Bicc1 and SamCystin interact at the protein level suggesting that they function in a common molecular pathway that when perturbed, is involved in cystogenesis.
Data report that targeted inactivation of BicC randomizes left-right asymmetry by disrupting the planar alignment of motile cilia required for cilia-driven fluid flow, and that BicC can uncouple Dvl2 (zeige DVL2 ELISA Kits) signaling from the canonical Wnt (zeige WNT2 ELISA Kits) pathway.
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.
bicaudal C homolog 1 (Drosophila)
, bicaudal C homolog 1-like
, bicaudal C homolog 1
, protein bicaudal C homolog 1-like
, protein bicaudal C homolog 1
, juvenile congenital polycystic kidney disease
, polycystic kidney mutation of BALB/c origin