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BATF3 encodes a member of the basic leucine zipper protein family.
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The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 (zeige IL19 ELISA Kits) expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019).
Basic Leucine Zipper ATF-Like Transcription Factor 3 (zeige TCF3 ELISA Kits) (BATF3), an AP-1 (zeige FOSB ELISA Kits) family transcription factor, is a glucocorticoid receptor (zeige NR3C1 ELISA Kits) coregulator whose interaction with glucocorticoid receptor (zeige NR3C1 ELISA Kits) is modulated by the lever arm.
Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens.
correlation of transcriptional repression by p21 (zeige CDKN1A ELISA Kits)(SNFT) with changes in DNA.NF-AT complex interactions
overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 (zeige MMP1 ELISA Kits) by 70-80%
The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery. We found that expression of Batf3 was selectively low in Treg cells but not in effector CD4 (zeige CD4 ELISA Kits) T (Teff) cells and that ectopic expression of Batf3 caused a marked reduction in the number of Foxp3 (zeige FOXP3 ELISA Kits)+ Treg cells. Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation.
in contrast to adult mice, Batf3-dependent dendritic cells were absolutely required for generating rotavirus-specific CD8 (zeige CD8A ELISA Kits)+ T-cell responses in neonates
Batf3(-/-) mice remained competent for skin graft rejection and delayed hypersensitivity, and retained a CD8 (zeige CD8A ELISA Kits)(+) dendritic cell population.
Lack of Batf3/CD103(+) dendritic cells within the tumor microenvironment dominantly resists the effector phase of an anti-tumor T cell response, contributing to immune escape.
study reports that Batf3 is critical for accumulation of CD103(+) DCs in the kidney and tongue at steady state, for their expansion during systemic and oropharyngeal candidiasis, and for tissue-specific production of IL-12 (zeige IL12A ELISA Kits) in kidney but not tongue during systemic and oropharyngeal candidiasis, respectively
this study shows that Batf3 promotes priming of CD8 (zeige CD8A ELISA Kits)+ T cells regardless of the location of Salmonella enterica antigen
Batf3 deficiency is not critical for the generation of CD8alpha dendritic cells.
Data indicte that interferon regulatory factor 8 (IRF8 (zeige IRF8 ELISA Kits)) expression becomes dependent on transcription factor Batf3.
IL-12 (zeige IL12A ELISA Kits) production by Batf3-dependent CD103+ dendritic cells is crucial for maintenance of local Th1 (zeige HAND1 ELISA Kits) immunity against L. major infection.
The basic leucine zipper ATF-like 3 (BATF3)- dendritic cell lineage is enriched in the lungs of asthma-protected mice and strictly required for protection.
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.
basic leucine zipper transcription factor, ATF-like 3
, basic leucine zipper transcriptional factor ATF-like 3
, Basic leucine zipper transcriptional factor ATF-like 3
, 21 kDa small nuclear factor isolated from T-cells
, 21-kD small nuclear factor isolated from T cells
, Jun dimerization protein 1
, Jun dimerization protein p21SNFT