anti-B-Cell Linker (BLNK) Antikörper

BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. Zusätzlich bieten wir Ihnen B-Cell Linker Kits (35) und B-Cell Linker Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BLNK 17060 Q9QUN3
BLNK 29760 Q8WV28
BLNK 499356 Q4KM52
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Top anti-B-Cell Linker Antikörper auf antikoerper-online.de

Showing 10 out of 230 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-BLNK Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  NCI-H226 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, FACS, IF, WB ABIN184602 staining (4µg/ml) of Daudi lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. ABIN184602 (0.3µg/ml) staining of Daudi cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of BLNK (arrow) using rabbit polyclonal BLNK Antibody (N-term) (ABIN657356). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the BLNK gene. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of BLNK staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of BLNK expression in Raji (A), LOVO (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from K562 cells treated with starved 24h, using BLNK (Phospho-Tyr84) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using BLNK (Phospho-Tyr84) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert ELISA, FACS, ICC, IHC, WB Red: Control Antigen (100ng);Purple: Antigen (10ng);Green: Antigen (50ng);Blue: Antigen (100ng); Dilution: 1/10000 Figure 1: Western blot analysis using BLNK mAb against human BLNK (AA: 34-216) recombinant protein. (Expected MW is 60 kDa)  Dilution: 1/500 - 1/2000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$577.50
Details
Human Maus Unkonjugiert ELISA, FACS, IF, IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from LOVO cells, treated with etoposide 25uM 24h, using BLNK (Ab-96) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using BLNK (Ab-96) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, using BLNK (Phospho-Tyr96) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lymph node, using BLNK (Phospho-Tyr96) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Rind (Kuh) Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 4 bis 8 Tage
$462.00
Details

Am meisten referenzierte anti-B-Cell Linker Antikörper

  1. Human Monoclonal BLNK Primary Antibody für ICS - ABIN1176912 : Li, Martin, Oliver, Kearney, Carter: Antigen receptor proximal signaling in splenic B-2 cell subsets. in Journal of immunology (Baltimore, Md. : 1950) 2001 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) Polyclonal BLNK Primary Antibody für WB - ABIN541866 : Jumaa, Mitterer, Reth, Nielsen: The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage. in European journal of immunology 2001 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal BLNK Primary Antibody für ICS - ABIN1177037 : Espeli, Mancini, Breton, Poirier, Schiff: Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. in Blood 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal BLNK Primary Antibody für ICC, FACS - ABIN968984 : Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal BLNK Primary Antibody für ICS - ABIN1177038 : Chiu, Dalton, Ishiai, Kurosaki, Chan: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. in The EMBO journal 2002 (PubMed)

  6. Human Polyclonal BLNK Primary Antibody für IF (p), IHC (p) - ABIN750038 : Luger, Yang, Raviv, Weinberg, Banerjee, Lee, Trepel, Yang, Wakefield: Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. in PLoS ONE 2013 (PubMed)

Weitere Antikörper gegen B-Cell Linker Interaktionspartner

Mouse (Murine) B-Cell Linker (BLNK) Interaktionspartner

  1. The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway.

  2. Authors demonstrate leukemogenicity of PAX5-PML by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5-PML in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5-PML.

  3. B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.

  4. Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B in the B cell lineage.

  5. a novel negative feedback regulation of BCR signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK

  6. CMTM7 functions to link sIgM and BLNK in the plasma membrane.

  7. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.

  8. malignant transformation of Btk/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.

  9. Swip-1 provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent BCR-induced calcium flux.

  10. malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway

  11. role in B cell Ag receptor-mediated antigen processing

  12. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

  13. role for BLNK and perhaps BCR signaling, in the regulation of kappa light chain expression and continued immature B cell differentiation

  14. BLNK as a direct target of the transcription factor Pax5

  15. SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor.

  16. Differentiation regulator SLP-65 (an adaptor protein also called BLNK or BASH) inhibits pre-B-cell leukaemia in mice

  17. constitutive active Btk can substitute for SLP-65 as a tumor suppressor.

  18. adaptor proteins LAT and SLP-76 are involved in pre-BCR signaling, thereby rescuing arrested murine SLP-65(-/-) pre-B cells

  19. SLP65/BLNK is a substrate of SHP-1.

  20. bone marrow-derived macrophages mice lacking both SLP-76 and SLP-65 demonstrated normal FcgammaR-mediated activation

Human B-Cell Linker (BLNK) Interaktionspartner

  1. vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR activation.

  2. early Ca(2+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 C2 domain to phospho-SLP65.

  3. up-regulation of BLNK is associated with RUNX1 mutations in cytogenetically normal acute myeloid leukemia.

  4. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.

  5. 16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression

  6. The BLNK protein is present in the majority of mediastinal B cell lymphomas.

  7. In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.

  8. V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.

  9. Syk is required to link phosphorylated SLP-65 to Ca(2+) mobilization.

  10. Plasmacytoid dendritic cells express a signalosome consisting of Lyn, Syk, Btk, Slp65 (Blnk) and PLCgamma2. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 & cytoskeletal proteins.

  11. BLNK prevents aneuploidy by inhibiting cytokinesis.

  12. BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation

  13. Data show that SLP-65 phosphorylation acts upstream for signal initiation and also downstream during selective processing of the B cell receptor signal.

  14. Identifies BLNK as a potential target for the protein-tyrosine phosphatase SHP-1.

B-Cell Linker (BLNK) Antigen-Profil

Protein Überblick

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-B-Cell Linker (BLNK) Antikörper

  • B-cell linker (BLNK) Antikörper
  • B-cell linker (blnk) Antikörper
  • B cell linker (Blnk) Antikörper
  • B-cell linker (Blnk) Antikörper
  • AGM4 Antikörper
  • BASH Antikörper
  • bca Antikörper
  • blnk Antikörper
  • BLNK-S Antikörper
  • Ly-57 Antikörper
  • LY57 Antikörper
  • Lyw-57 Antikörper
  • MGC147045 Antikörper
  • SLP-65 Antikörper
  • SLP65 Antikörper

Bezeichner auf Proteinebene für anti-B-Cell Linker (BLNK) Antikörper

B-cell linker , B-cell linker protein , b-cell linker protein-like , B-cell adapter containing a SH2 domain protein , B-cell adapter containing a Src homology 2 domain protein , cytoplasmic adapter protein , lymphocyte antigen 57 , src homology 2 domain-containing leukocyte protein of 65 kDa , B cell adaptor containing SH2 domain , B cell linker protein , B-cell activation , Src homology 2 domain-containing leukocyte protein of 65 kDa , Src homology [SH2] domain-containing leukocyte protein of 65 kD , B cell linker protein BLNK , B-cell adapter SH2 domain-containing protein , SLP-65

GENE ID SPEZIES
100070841 Equus caballus
405764 Danio rerio
450641 Pan troglodytes
548350 Xenopus (Silurana) tropicalis
704363 Macaca mulatta
100306798 Salmo salar
100456635 Pongo abelii
100481331 Ailuropoda melanoleuca
100593492 Nomascus leucogenys
17060 Mus musculus
29760 Homo sapiens
395733 Gallus gallus
499356 Rattus norvegicus
486814 Canis lupus familiaris
100152350 Sus scrofa
510393 Bos taurus
100712978 Cavia porcellus
101111241 Ovis aries
100354716 Oryctolagus cuniculus
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