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Regulates autophagy and development of the nervous system. Zusätzlich bieten wir Ihnen AMBRA1 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal AMBRA1 Primary Antibody für ICC, IF - ABIN446495
Falasca, Torino, Marconi, Costantini, Pompeo, Sentinelli, De Salvo, Patrizio, Padula, Gallucci, Piacentini, Malorni: AMBRA1 and SQSTM1 expression pattern in prostate cancer. in Apoptosis : an international journal on programmed cell death 2015
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Human Polyclonal AMBRA1 Primary Antibody für IP, IHC - ABIN347117
Fimia, Stoykova, Romagnoli, Giunta, Di Bartolomeo, Nardacci, Corazzari, Fuoco, Ucar, Schwartz, Gruss, Piacentini, Chowdhury, Cecconi: Ambra1 regulates autophagy and development of the nervous system. in Nature 2007
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Human Polyclonal AMBRA1 Primary Antibody für IF (p), IHC (p) - ABIN704741
Song, Kou, Zou, Gao, Zeng, Xie: Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens. in Neurochemistry international 2013
Ambra1 knockdown causes severe embryonic malformations.
Results showed that AMBRA1 is a novel hub binding protein of alpha-synuclein and plays a central role in the pathogenesis of multiple system atrophy through the degradative dynamics of alpha-synuclein.
MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1 (zeige BECN1 Antikörper)-mediated autophagy.
Data support a role of AMBRA1/Ambra1 partial loss-of-function genotypes for female autistic traits. Moreover, they suggest Ambra1 heterozygous mice as a novel multifaceted and construct-valid genetic mouse model for female autism.
Ambra1 binds to both FAK (zeige PTK2 Antikörper) and Src (zeige SRC Antikörper) in cancer cells. When FAK (zeige PTK2 Antikörper) is present, Ambra1 is recruited to focal adhesions, promoting FAK (zeige PTK2 Antikörper)-regulated cancer cell direction-sensing and invasion. However, when Ambra1 cannot bind to FAK (zeige PTK2 Antikörper), abnormally high levels of phospho-Src (zeige SRC Antikörper) and phospho-FAK (zeige PTK2 Antikörper) accumulate at focal adhesions, positively regulating adhesion and invasive migration.
The results suggested that AMBRA1 is a core factor that controls both autophagy and metabolic regulation.
we further measured the expression of autophagy protein BECLIN1 (zeige BECN1 Antikörper) in hippocampus of all mice
a de-regulation of c-Myc (zeige MYC Antikörper) correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.
found Smad2 (zeige SMAD2 Antikörper) as the major transcriptional regulator of autophagy that targets beclin1 (BECN1 (zeige BECN1 Antikörper)) gene expression. Smad2 (zeige SMAD2 Antikörper), but not Smad3 (zeige SMAD3 Antikörper), acts as a repressor upstream of the BECN1 (zeige BECN1 Antikörper) promoter region
AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics
These results reveal new roles for autophagy-related molecules Atg5 (zeige ATG5 Antikörper) and Ambra1 during early neuronal differentiation of stem/progenitor cells.
Ambra1 plays an important role in regulating the sensitivity of breast cancer cells to epirubicin. Regulatory effect of Ambra1 on epirubicin sensitivity is achieved through the regulation of autophagy by targeting ATG12.
These data suggest a new and interesting role of MIR7-3HG as an anti-autophagic MIRNA that may affect oncogenesis through the regulation of the tumor suppressor AMBRA1.
Results show that the expression of AMBRA1 and Beclin-1 (zeige BECN1 Antikörper) is increased in human gastric adenocarcinoma (GC) tissues. High protein expression of AMBRA1 and Beclin-1 (zeige BECN1 Antikörper) is correlated with tumor invasion and is an independent poor prognostic marker in GC patients.
Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.
An increased expression of AMBRA1 and SQSTM1 (zeige SQSTM1 Antikörper).
Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.
Both AMBRA1 and BECLIN 1 (zeige BECN1 Antikörper) affect c-Myc (zeige MYC Antikörper) regulation, but through two different pathways.
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
autophagy/beclin-1 regulator 1
, activating molecule in BECN1-regulated autophagy protein 1-like
, activating molecule in BECN1-regulated autophagy protein 1
, activating molecule in Beclin1-regulated autophagy
, ischemia related factor NYW-1
, DDB1 and CUL4 associated factor 3
, WD repeat domain 94
, activating molecule in beclin-1-regulated autophagy