anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) Antikörper

Regulates autophagy and development of the nervous system. Zusätzlich bieten wir Ihnen AMBRA1 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
AMBRA1 228361 A2AH22
AMBRA1 59319  
AMBRA1 55626 Q9C0C7
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Top anti-AMBRA1 Antikörper auf antikoerper-online.de

Showing 10 out of 145 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IHC, ELISA, WB 0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$446.35
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of AMBRA1 expression in 293T (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IP, IHC, ELISA, WB 200 μL Anmelden zum Anzeigen 6 bis 7 Tage
$509.40
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of MCF7 and A431 cells, using FLJ20294 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$366.77
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of AMBRA1 Antibody (N-term) in HepG2 cell line lysates (35 µg/lane). AMBRA1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with AMBRA1 antibody (N-term) (ABIN388572), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: AMBRA1 Antibody [NBP1-30460] - Whole cell lysate from HeLa and 293T cells. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$559.35
Details
Huhn Kaninchen Unkonjugiert IHC, IHC (p), WB Anti-AMBRA1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1099960 dilution 10 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western blot analysis of MCF7  using AMBRA1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276497 at 1/100 staining Human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded labeled with rat brain Anti-AMBRA1 Polyclonal Antibody, Unconjugated (ABIN704741) 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat lung labeled with Rabbit Anti-AMBRA1 Polyclonal Antibody, Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$329.45
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with AMBRA1 antibody ABIN461918 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Kidney (formalin-fixed, paraffin-embedded) stained with AMBRA1 antibody ABIN461918 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-AMBRA1 Antikörper

  1. Human Polyclonal AMBRA1 Primary Antibody für ICC, IF - ABIN446495 : Falasca, Torino, Marconi, Costantini, Pompeo, Sentinelli, De Salvo, Patrizio, Padula, Gallucci, Piacentini, Malorni: AMBRA1 and SQSTM1 expression pattern in prostate cancer. in Apoptosis : an international journal on programmed cell death 2015 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal AMBRA1 Primary Antibody für IP, IHC - ABIN347118 : Fimia, Stoykova, Romagnoli, Giunta, Di Bartolomeo, Nardacci, Corazzari, Fuoco, Ucar, Schwartz, Gruss, Piacentini, Chowdhury, Cecconi: Ambra1 regulates autophagy and development of the nervous system. in Nature 2007 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal AMBRA1 Primary Antibody für IHC (p), WB - ABIN541710 : Kisen, Tessitore, Costelli, Gordon, Schwarze, Baccino, Seglen: Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. in Carcinogenesis 1994 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal AMBRA1 Primary Antibody für IHC (p), WB - ABIN541709 : Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal AMBRA1 Primary Antibody für IF (p), IHC (p) - ABIN704741 : Song, Kou, Zou, Gao, Zeng, Xie: Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens. in Neurochemistry international 2013 (PubMed)

Weitere Antikörper gegen AMBRA1 Interaktionspartner

Zebrafish Autophagy/beclin-1 Regulator 1 (AMBRA1) Interaktionspartner

  1. ambra1a and ambra1b are required for the correct development and morphogenesis of skeletal muscle.

  2. Ambra1 knockdown causes severe embryonic malformations.

Mouse (Murine) Autophagy/beclin-1 Regulator 1 (AMBRA1) Interaktionspartner

  1. these findings identify an Ambra1-dependent mechanism that drives inhibition/excitation imbalance in the hippocampus, contributing to abnormal brain activity reminiscent of neurodevelopmental disorders.

  2. Results showed that AMBRA1 is a novel hub binding protein of alpha-synuclein and plays a central role in the pathogenesis of multiple system atrophy through the degradative dynamics of alpha-synuclein.

  3. MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy.

  4. Data support a role of AMBRA1/Ambra1 partial loss-of-function genotypes for female autistic traits. Moreover, they suggest Ambra1 heterozygous mice as a novel multifaceted and construct-valid genetic mouse model for female autism.

  5. Ambra1 binds to both FAK and Src in cancer cells. When FAK is present, Ambra1 is recruited to focal adhesions, promoting FAK-regulated cancer cell direction-sensing and invasion. However, when Ambra1 cannot bind to FAK, abnormally high levels of phospho-Src and phospho-FAK accumulate at focal adhesions, positively regulating adhesion and invasive migration.

  6. The results suggested that AMBRA1 is a core factor that controls both autophagy and metabolic regulation.

  7. we further measured the expression of autophagy protein BECLIN1 in hippocampus of all mice

  8. a de-regulation of c-Myc correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

  9. found Smad2 as the major transcriptional regulator of autophagy that targets beclin1 (BECN1) gene expression. Smad2, but not Smad3, acts as a repressor upstream of the BECN1 promoter region

  10. AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics

  11. It plays a fundamental role in regulating the autophagic process in developing nervous tissue.

  12. These results reveal new roles for autophagy-related molecules Atg5 and Ambra1 during early neuronal differentiation of stem/progenitor cells.

  13. These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy.

  14. Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death

Human Autophagy/beclin-1 Regulator 1 (AMBRA1) Interaktionspartner

  1. AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKalpha are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells.

  2. Ambra1 plays an important role in regulating the sensitivity of breast cancer cells to epirubicin. Regulatory effect of Ambra1 on epirubicin sensitivity is achieved through the regulation of autophagy by targeting ATG12.

  3. Results showed that AMBRA1 is a novel hub binding protein of alpha-synuclein and plays a central role in the pathogenesis of multiple system atrophy through the degradative dynamics of alpha-synuclein.

  4. Data support a role of AMBRA1/Ambra1 partial loss-of-function genotypes for female autistic traits. Moreover, they suggest Ambra1 heterozygous mice as a novel multifaceted and construct-valid genetic mouse model for female autism.

  5. These data suggest a new and interesting role of MIR7-3HG as an anti-autophagic MIRNA that may affect oncogenesis through the regulation of the tumor suppressor AMBRA1.

  6. Results show that the expression of AMBRA1 and Beclin-1 is increased in human gastric adenocarcinoma (GC) tissues. High protein expression of AMBRA1 and Beclin-1 is correlated with tumor invasion and is an independent poor prognostic marker in GC patients.

  7. Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy.

  8. An increased expression of AMBRA1 and SQSTM1.

  9. a de-regulation of c-Myc correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

  10. Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death.

  11. Both AMBRA1 and BECLIN 1 affect c-Myc regulation, but through two different pathways.

  12. AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics

  13. Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells

  14. A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level.

  15. Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5, Ambra1, beclin-1, LC3B and Bif-1 is significantly correlated with poor outcome.

  16. role that Ambra1 in the switch between autophagy and apoptosis

  17. findings show under non-autophagic conditions, mTOR inhibits AMBRA1 by phosphorylation, whereas on autophagy induction, AMBRA1 is dephosphorylated; in this condition, AMBRA1, interacting with TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its stabilization, self-association and function

  18. Ambra1 is an important target of apoptotic proteases resulting in the dismantling of the autophagic machinery and the accomplishment of the cell death program

  19. In this study, the authors show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction.

  20. When autophagy is induced, ULK1 phosphorylates AMBRA1, releasing the autophagy core complex from dynein.

AMBRA1 Antigen-Profil

Protein Überblick

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.

Genbezeichner und Symbole assoziert mit AMBRA1

  • autophagy and beclin 1 regulator 1 (AMBRA1) Antikörper
  • autophagy/beclin-1 regulator 1a (ambra1a) Antikörper
  • autophagy/beclin 1 regulator 1 (Ambra1) Antikörper
  • autophagy and beclin 1 regulator 1 (Ambra1) Antikörper
  • 2310079H06Rik Antikörper
  • A130023A14 Antikörper
  • AA474864 Antikörper
  • AV021921 Antikörper
  • D030051N19Rik Antikörper
  • DCAF3 Antikörper
  • mKIAA1736 Antikörper
  • Nyw1 Antikörper
  • WDR94 Antikörper

Bezeichner auf Proteinebene für AMBRA1

autophagy/beclin-1 regulator 1 , activating molecule in BECN1-regulated autophagy protein 1-like , activating molecule in BECN1-regulated autophagy protein 1 , activating molecule in Beclin1-regulated autophagy , ischemia related factor NYW-1 , DDB1 and CUL4 associated factor 3 , WD repeat domain 94 , activating molecule in beclin-1-regulated autophagy

GENE ID SPEZIES
100050652 Equus caballus
451154 Pan troglodytes
714434 Macaca mulatta
100385379 Callithrix jacchus
100471614 Ailuropoda melanoleuca
100219120 Taeniopygia guttata
100332642 Danio rerio
228361 Mus musculus
59319 Rattus norvegicus
55626 Homo sapiens
423194 Gallus gallus
517263 Bos taurus
483634 Canis lupus familiaris
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