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ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Zusätzlich bieten wir Ihnen Asporin Kits (39) und Asporin Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal Asporin Primary Antibody für ICC, IF - ABIN250383
Yang, Nyalwidhe, Guo, Drake, Semmes: Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. in Molecular & cellular proteomics : MCP 2011
Show all 2 Pubmed References
Human Polyclonal Asporin Primary Antibody für ICC, IF - ABIN4281912
Murphy, Dowling, Zweyer, Mundegar, Henry, Meleady, Swandulla, Ohlendieck: Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy. in Journal of proteomics 2016
higher expression of asporin was noticed in CRC (zeige CALR Antikörper) tissues and it was correlated with later clinical stage of the patients. Asporin promoted the migration and invasion of the tumor cells partially through an EGFR (zeige EGFR Antikörper)/Src (zeige SRC Antikörper)/cortactin (zeige CTTN Antikörper)- signaling pathway.
ASPN D15 (zeige MRPL16 Antikörper) is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
we found that asporin can be downregulated by bone morphogenetic protein 4 (zeige BMP4 Antikörper) in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth
Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (zeige CD44 Antikörper)-AKT (zeige AKT1 Antikörper)/ERK (zeige EPHB2 Antikörper)-NF-kappaB (zeige NFKB1 Antikörper) pathway in paracrine and autocrine manner.
High ASPN expression in stroma is associated with prostate cancer progression.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (zeige EGFR Antikörper) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA
Osteomodulin (zeige OMD Antikörper), osteoglycin (zeige OGN Antikörper), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Asporin deficiency changes skin glycosaminoglycan composition, and decorin (zeige DCN Antikörper) and biglycan (zeige BGN Antikörper) content, which may explain the changes in skin mechanical properties.
inhibition of TLR2- and TLR4 (zeige TLR4 Antikörper)-induced inflammatory responses and binding abilities to TLR2 and TLR4 (zeige TLR4 Antikörper)
positively regulates FGF-2 (zeige FGF2 Antikörper) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (zeige MMRN1 Antikörper) and TGF-beta1 (zeige TGFB1 Antikörper) and thereby modulates interactions between TGF-beta (zeige TGFB1 Antikörper) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (zeige BMP2 Antikörper) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (zeige TGFB1 Antikörper) induces ASPN through Smad3 (zeige SMAD3 Antikörper) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (zeige BMP2 Antikörper) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Mapping of the OGN (zeige OGN Antikörper) and ASPN genes and association with growth and carcass traits.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, biglycan-like protein 3
, periodontal ligament-associated protein 1