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ASAP3 encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. Zusätzlich bieten wir Ihnen ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Results show that ASAP3 was amplified in colorectal cancer (CRC (zeige CALR Antikörper)) tissues, and its upregulation was associated with poor prognosis of patients with CRC (zeige CALR Antikörper). Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO (zeige IKBKG Antikörper). These results suggest that ASAP3 acts as an oncogene (zeige RAB1A Antikörper).
The data, for the first time, link ASAP3 with ACTG1 (zeige ACTG1 Antikörper) in the regulation of cytoskeletal maintenance and cell motility
). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion.
Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin (zeige AMPH Antikörper), and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF (zeige EGF Antikörper))-elicited membrane remodeling.
ACAP4 protein cooperates with Grb2 (zeige GRB2 Antikörper) protein to orchestrate epidermal growth factor (zeige EGF Antikörper)-stimulated integrin beta1 recycling in cell migration
The ArfGAP catalytic mechanism and shows a glutamine (zeige GFPT1 Antikörper) from Arf6 (zeige ARF6 Antikörper) and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.
ACAP4 is involved in ARF6 (zeige ARF6 Antikörper)-mediated cell migration.
ASAP3 functions nonredundantly with ASAP1 (zeige ASAP1 Antikörper) to control cell movement and may have a role in cancer cell invasion.
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1
, development and differentiation enhancing factor-like 1
, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
, ARF6 GTPase-activating protein
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
, centaurin, beta 6
, development and differentiation-enhancing factor-like 1
, protein up-regulated in liver cancer 1
, up-regulated in liver cancer 1 (UPLC1)