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APOBEC3B is a member of the cytidine deaminase gene family. Zusätzlich bieten wir Ihnen APOBEC3B Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal APOBEC3B Primary Antibody für WB - ABIN5572734
Yan, He, Gao, Wu, Li, Huang, Liang, Wu, Li: Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study. in Journal of Cancer 2016
This study found that A3B (zeige SGCB Antikörper) C-terminal domain shows higher activity toward its target sequence in short ssDNA and efficiently deaminates a target sequence located near the center of ssDNA.
Data show that the larger oligomeric state of APOBEC3B (A3B (zeige SGCB Antikörper)) inhibited its activity.
APOBEC3B*c.783delG showed evidence of modest association with breast cancer and seemed to contribute to earlier onset of the disease.
Data show that APOBEC3B (A3B (zeige SGCB Antikörper)) expression is inversely related to p53 (zeige TP53 Antikörper) status in different cancer types and demonstrate that this is due to a direct and pivotal role for p53 (zeige TP53 Antikörper) in repressing A3B (zeige SGCB Antikörper) expression.
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation have been reported.
A lysine-free derivative of human APOBEC3B was constructed and shown to be indistinguishable from the wild-type enzyme in DNA cytosine deamination, HIV-1 restriction, and nuclear localization activities.
exposures to relevant environmental factors might induce APOBEC3A (zeige APOBEC3A Antikörper) or APOBEC3B expression above genotoxic levels and initiate tumorigenesis in a tissue-specific manner in the right cellular environment where ssDNA is available
APOBEC3B expression increased the incorporation of genomic uracil, invoked DNA damage response (DDR (zeige DDR1 Antikörper)) biomarkers and caused cell cycle arrest.
The findings demonstrate that covalently-closed circular DNA levels are significantly lower in hepatocellular carcinoma tissues, and that the lower levels are likely to stem in part from up-regulation of APOBEC3B.
Data suggest that heat shock proteins, in particular Hsp90 (zeige HSP90 Antikörper), stimulate APOBEC3 (zeige APOBEC3F Antikörper)-mediated DNA deamination activity toward hepatitis B viral DNA, suggesting a potential physiological role in mutagenesis/carcinogenesis and viral innate immunity; Hsp90 (zeige HSP90 Antikörper) stimulates deamination activity of APOBEC3G (zeige APOBEC3G Antikörper), APOBEC3B, and APOBEC3C (zeige APOBEC3C Antikörper) during co-expression in human liver HepG2 cells.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
, probable DNA dC->dU-editing enzyme APOBEC-3B
, apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B
, DNA dC->dU-editing enzyme APOBEC-3B
, cytidine deaminase
, phorbolin 2
, phorbolin 3
, phorbolin-1-related protein
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
, DNA dC->dU-editing enzyme APOBEC3
, apolipoprotein B editing complex 3
, probable DNA dC->dU-editing enzyme APOBEC3