Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. Zusätzlich bieten wir Ihnen EHMT2 Proteine (7) und EHMT2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 60 products:
Human Polyclonal EHMT2 Primary Antibody für ICC, IF - ABIN251509
Cho, Kelly, Hayami, Toyokawa, Takawa, Yoshimatsu, Tsunoda, Field, Neal, Ponder, Nakamura, Hamamoto: Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. in Neoplasia (New York, N.Y.) 2011
Show all 2 Pubmed References
Cow (Bovine) Polyclonal EHMT2 Primary Antibody für ChIP, WB - ABIN2779680
Kondo, Shen, Ahmed, Boumber, Sekido, Haddad, Issa: Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. in PLoS ONE 2008
Human Polyclonal EHMT2 Primary Antibody für ICC, IF - ABIN4313049
Mauger, Klinck, Chabot, Muchardt, Allemand, Batsché: Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions. in Nucleic acids research 2015
Regulated methylation and phosphorylation serve as a switch controlling G9a and GLP (zeige RCBTB1 Antikörper) coactivator function, suggesting that this mechanism may be a general paradigm for directing specific transcription factor and coregulator actions on different genes.
interleukin-8 (zeige IL8 Antikörper) is a downstream effector of G9a to increase gemcitabine resistance in pancreatic cancer. Overexpression of G9a correlated with poor survival and early recurrence in pancreatic cancer patients.
Taken together, our findings provide evidence that G9a protects head and neck squamous cell carcinomas (HNSCC)cells against chemotherapy by increasing the synthesis of GSH, and imply G9a as a promising target for overcoming cisplatin resistance in HNSCC
In this study, EHMT2 (a histone methyltransferase) was determined to be significantly overexpressed in breast cancer tissues and in Oncomine data. In addition, knockdown of EHMT2 reduced cell migration and invasion.
Knockdown of G9a increased the sensitivity of cells to radiation treatment and sensitized cells to DNA damage agents through PP2A-RPA axis.
EHMT2 can directly repress Beclin-1 (zeige BECN1 Antikörper) and the inhibition of EHMT2 may be a useful therapeutic approach for cancer prevention by activating autophagy
IFNgamma induced PPAR gamma coactivator-1 alpha (PGC-1alpha) positively regulated RIG-I; with PRMT-1 and G9a affecting PGC-1alpha in a counter-regulatory manner.
Loss of miR-1 (zeige FSD1 Antikörper) and gene copy number gain of G9a contributed to its frequent upregulation in liver cancer, which epigenetically silenced the expression of tumor suppressor RARRES3 (zeige RARRES3 Antikörper), and ultimately contributed to hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cell proliferation and migration.
G9a promotes breast cancer by regulating iron metabolism through the repression of ferroxidase (zeige CP Antikörper) hephaestin (zeige HEPH Antikörper).
study uncovers a novel mechanism of G9A promoting tumor cell growth and invasion by silencing CASP1 (zeige CASP1 Antikörper), and implies that G9A may serve as a therapeutic target in treating Non-small-cell lung cancer.
These results suggest that PIA2 modulates phyA-mediated PIF3 phosphorylation by physical interaction with PIF3 and that the secondary structure of the PIA2 N-terminus is important in this modulation.
These results identify G9a-induced histone methylation at the OXT (zeige OXT Antikörper) and AVP (zeige AVP Antikörper) promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise.
The findings of this study suggested that G9a participates in the nerve injury-induced reduction of the Oprm1 gene likely through G9a-triggered blockage in the access of cyclic AMP response element binding protein to this gene.
GLP (zeige GOLGA6A Antikörper)/G9a H3K9 methyltransferase complex is an enzyme counteracting Jmjd1a (zeige KDM3A Antikörper)-mediated H3K9 demethylation at the Sry (zeige SRY Antikörper) locus in gonadal somatic cells
G9a regulates cell proliferation and timing of differentiation and that G9a expression in the tooth mesenchyme is required for proper tooth development
Jmjd2c (zeige KDM4C Antikörper) and G9a are novel enhancer-associated factors. Loss of Jmjd2c (zeige KDM4C Antikörper) abrogates G9a recruitment and further destabilises loading of the mediator and cohesin components Med1 (zeige MBD4 Antikörper) and Smc1a (zeige SMC1A Antikörper) at newly activated and poised enhancers in embryonic stem cell-derived epiblast-like cells.
G9a is an important regulator in placental diseases caused by defective vascular maturation.
miR (zeige MLXIP Antikörper)-217-mediated, genetic, or pharmacological inactivation of EHMT1 (zeige EHMT1 Antikörper)/2 was sufficient to promote pathological hypertrophy
G9A overexpression is associated with peritoneal fibrosis.
high levels of G9a-dependent H3K9me2 at ILC3-specific genetic loci, demonstrating that G9a-mediated repression of ILC3-associated genes is critical for the optimal development of ILC2s.
G9a functions both as a co-activator and a co-repressor to enhance cellular proliferation and inhibit myogenic differentiation.
EHMT2 inhibitor BIX-01294 is a potent inhibitor of H3K9 dimethylation and transient alterations in global histone modifications can have profound effects on embryo developmental potential.
The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition.
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster\; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.
G9A histone methyltransferase
, H3-K9-HMTase 3
, HLA-B associated transcript 8
, HLA-B-associated transcript 8
, ankyrin repeat-containing protein
, histone H3-K9 methyltransferase 3
, histone-lysine N-methyltransferase EHMT2
, histone-lysine N-methyltransferase, H3 lysine-9 specific 3
, lysine N-methyltransferase 1C
, protein G9a
, euchromatic histone-lysine N-methyltransferase 2
, HLA-B associated transcript 8, rat orthologue