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ANKH encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Zusätzlich bieten wir Ihnen ANKH Antikörper (33) und ANKH Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Data indicate that ankylosis gene product ANK siRNA suppressed basal and hypotonically-stressed ATP levels.
Results show that ANK localizes to the trans-Golgi network (TGN), clathrin-coated vesicles and the plasma membrane, and is required for endosomal function and endocytosis
This study validates the association between a functional polymorphism in the 5' UTR (zeige UTS2R ELISA Kits) of ANKH and Chondrocalcinosis
Polymorphisms in ALP (zeige ALP ELISA Kits), ENPP1 (zeige ENPP1 ELISA Kits) and ANKH are important genetic risk factors contributing to Pseudoxanthoma elasticum
ANK (zeige ANK1 ELISA Kits) was concentrated around crystal deposits and correlated with markers of chondrocyte hypertrophy. These findings support a role for ANK (zeige ANK1 ELISA Kits) in CPPD crystal formation in cartilage.
expression levels of type II collagen (zeige COL2A1 ELISA Kits), aggrecan (zeige ACAN ELISA Kits), and ANK (zeige ANK1 ELISA Kits) in endplate chondrocytes of experimental group were lower than that of control group and phosphorylation level of JNK (zeige MAPK8 ELISA Kits) in the experimental group which was higher than that in the control group
Analysis of the present CMD (zeige ACAN ELISA Kits) family suggested the presence of a maternal mosaicism in an ANKH mutation, and the mother who was mosaic for the ANKH mutation had no apparent clinical or radiological features of CMD (zeige ACAN ELISA Kits).
The aim of this study was to investigate two mineralization-related genes TNAP and ANKH polymorphisms associated with ankylosing spondylitis (AS) in the North Chinese Han population.
Neither ANKH nor ENPP1 (zeige ENPP1 ELISA Kits) mutations are the cause of chondrocalcinosis in these Slovakian families.
TNF (zeige TNF ELISA Kits)-activated NF-kappaB (zeige NFKB1 ELISA Kits) promotes inflammation-accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion.
We report a novel mutation, not previously described, in ANKH exon 1, wherein serine replaces proline, in a case of early-onset severe calcium pyrophosphate disease associated with metabolic abnormalities, with similar findings in the proband's father
our study provides evidence that ANK plays a critical role in the adipogenic/osteogenic fate decision of adult mesenchymal precursor cells
regulates the transport of inorganic pyrophosphate, and Ank knock-out mice feature a rapidly forming and thick cementum and increased cementum regeneration
Loss of Ank alters cementoblast gene expression and cervical cementum extracellular matrix composition.
the relationship between the type of temporomandibular disorders (TMD (zeige TTN ELISA Kits)) and ANKH polymorphisms
Phe377del mutation in ANK causes impaired osteoblastogenesis and osteoclastogenesis resulting in hypomineralization and a high bone mass phenotype.
ANK is a positive regulator of osteoblastic and osteoclastic differentiation events toward a mature osteoblastic and osteoclastic phenotype.
Analyses on mineralized tissues showed no decrease in mineralization between ank/ank cementum vs. WT controls. Nanoindentation on enamel, dentin or cementum of ank/ank vs. WT molars revealed no significant difference in hardness and elastic modulus.
endogenous expression of ANKH mRNA and protein in whole mouse kidney as well as mouse renal epithelial cell lines and a osteoblast cell line.
Linked regulatory effects on extracellular PP(i) and OPN (zeige SPP1 ELISA Kits) expression mediate the ability of PC-1 (zeige PCSK1 ELISA Kits) and ANK to regulate calcification.
intra-renal and subcellular localisation of ANK is consistent with pyrophosphate export from collecting duct cells and supports a role for ANK in limiting intra-renal calcium-crystal formation
This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia.
ankylosis, progressive homolog (mouse)
, progressive ankylosis protein
, progressive ankylosis protein homolog-like
, progressive ankylosis protein homolog
, ankylosis, progressive homolog
, progressive ankylosis-like protein
, progressive ankylosis homolog
, progressive ankylosis protein homolog B
, fn54 protein