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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. Zusätzlich bieten wir Ihnen Angiotensin II Receptor-Associated Protein Antikörper (48) und Angiotensin II Receptor-Associated Protein Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (zeige AGTR1 Proteine), plays a protective role against the development of systemic insulin (zeige INS Proteine) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein (zeige PITPNA Proteine) RdgBbeta (zeige PITPNC1 Proteine) binds 14-3-3 (zeige YWHAQ Proteine) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (zeige CSF2 Proteine) angiotensin II, ACE (zeige ACE Proteine), and ACE2 (zeige ACE2 Proteine) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (zeige AQP4 Proteine) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (zeige AGTR1 Proteine)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1 (zeige ARAP1 Proteine), which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (zeige EPHA3 Proteine)-293 cells
CAML (zeige CAMLG Proteine) is an important signal transducer for the actions of Ang II (zeige AGT Proteine) in regulating the calcineurin-NFAT (zeige NFATC1 Proteine) pathway and the interaction of CAML (zeige CAMLG Proteine) with ATRAP may mediate the Ang II (zeige AGT Proteine) actions in vascular physiology
ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1 (zeige SIRT1 Proteine)-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span.
Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin (zeige INS Proteine) resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling.
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein of the cardiac Ca(2+)-ATPase SERCA2a. Suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R (zeige P2RY6 Proteine) heterodimers with age may increase the likelihood of hypertension induced by Ang II (zeige AGT Proteine).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I