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Candidate tumor suppressor gene (By similarity).
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High AIG1 expression is associated with virulence in clinical isolates of Entamoeba histolytica.
These results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism.
identified a novel Pirh2 (zeige RCHY1 Antikörper)-interacting protein, AIG1, by yeast two-hybrid screening and confirmed its interaction with p53 (zeige TP53 Antikörper) both in vitro and in vivo
Immunoblotting of mouse tissues demonstrated highest expression of AIG1 in the liver, lung and heart. AIG1 has a complex genomic organization and expresses several splice variants in a tissue-dependent manner; AIG1 over-expression slightly increased susceptibility to oxidative stress. These results indicate that AIG1 plays a role in the control of the intracellular Ca(2 (zeige CA2 Antikörper)+) concentration and cell death susceptibility.
Candidate tumor suppressor gene (By similarity). May contribute to specialized endoplasmic reticulum functions in neurons (By similarity).
androgen-induced gene 1 protein