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The protein encoded by ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide.
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Mammalian Monoclonal ALDH1L1 Primary Antibody für ISt, IHC - ABIN1304519
Orr, Hsiao, Wang, Ho, Kim, Wang, Guo, Kang, Yu, Adame, Devidze, Dubal, Masliah, Conklin, Mucke: Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. in Nature neuroscience 2015
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Mammalian Monoclonal ALDH1L1 Primary Antibody für ISt, IHC - ABIN1304521
Barres: The mystery and magic of glia: a perspective on their roles in health and disease. in Neuron 2008
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Human Polyclonal ALDH1L1 Primary Antibody für IHC - ABIN965537
Chumanevich, Krupenko, Davies: The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain. in The Journal of biological chemistry 2004
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Human Polyclonal ALDH1L1 Primary Antibody für ELISA, WB - ABIN564710
Henkel, Roderfeld, Weiskirchen, Berres, Hillebrandt, Lammert, Meyer, Stühler, Graf, Roeb: Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis. in Proteomics 2006
Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 (zeige TP53 Antikörper) expression in HBV-related hepatocellular carcinoma patients
ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer
high transcription activities of ALDH1A2 (zeige ALDH1A2 Antikörper), ALDH1A3 (zeige ALDH1A3 Antikörper) and ALDH1L1 predicted worsen overall survival in gastric cancer patients
The three functional domains of ALDH1L1 was defined positions of the 4'-phosphopantetheine arm within the two catalytic domains and to predict N-terminal:intermediate and intermediate:C-terminal domain interfaces.
The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population.
Data suggest that isoforms of FTHFD occur both in mitochondria and in cytosol; activity of cytosolic FTHFD appears to respond to supply of one-carbon groups in excess (zeige RCC1 Antikörper) of those required for classical one-carbon metabolism. [REVIEW]
JNK1 (zeige MAPK8 Antikörper)/2 phosphorylate Bid (zeige BID Antikörper) at Thr59 within the caspase (zeige CASP3 Antikörper) cleavage site in response to ALDH1L1.
ALDH1 (zeige ALDH1A1 Antikörper) is indicative of stemness and is a biomarker marker in colon cancer.
one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke.
The results in this study, for the first time, reveal that the mRNA and protein expressions of ALDH1L1 are significantly reduced in hepatocellular carcinoma tissues
Collectively, MNSFbeta (zeige FAU Antikörper)/FDH (zeige ADH5 Antikörper) complex formation may positively regulate apoptosis in thymocytes.
Aldh1L1 is not a suitable marker for enteric glial cells.
This study demonistrated that Aldh1L1 is expressed by postnatal neural stem cells in mice.
These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells.
The crystal structures of apo (zeige C9orf3 Antikörper)-form N-terminal domain - FDH and its complexes with the substrate analogue 10-formyl-5,8-dideazafolate (10-FDDF) and with the products tetrahydrofolate and formate have been determined.
Knock-down of the fdh(10-Formyltetrahydrofolate dehydrogenase) gene impeded morphogenetic movement and caused incorrect cardiac positioning, defective hematopoiesis, notochord malformation and ultimate death of morphants
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
, cytosolic 10-formyltetrahydrofolate dehydrogenase
, aldehyde dehydrogenase family 1 member L1
, formyltetrahydrofolate dehydrogenase
, aldehyde dehydrogenase 1L1
, aldehyde dehydrogenase 1 family, member L1
, 10-formyltetrahydrofolate dehydrogenase-like