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The protein encoded by AKR7A2 belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones.
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Human Polyclonal AKR7A2 Primary Antibody für IP, WB - ABIN522046
Quiñones-Lombraña, Ferguson, Hageman Blair, Kalabus, Redzematovic, Blanco: Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome. in Pharmaceutical research 2014
AKR7A2 physically interacts with CYGB (zeige CYGB Antikörper).
AKR7A2 contributes to protection against MG-induced toxicity.
structure and tissue-related expression of AFAR genes on chromosome 1
The human aldo-keto reductase AKR7A2 has been proposed previously to catalyze the NADPH (zeige NQO1 Antikörper)-dependent reduction of succinic semialdehyde (SSA (zeige TRIM21 Antikörper)) to gamma-Hydroxybutyrate in human brain
The human AFAR gene family maps to a genomic region in 1p36 of frequent hemizygous deletions in various human cancers.
Aflatoxin B(1) aldehyde reductase (zeige ADH1B Antikörper) (AKR7A2) was confirmed to be only highly expressed in pancreatic cancer, not in normal adjacent pancreas and benign tumors.
These findings indicate the importance of AKR7A5 in protecting cells from the damaging effects of oxidative stress, and that this cytoprotective function is carried out through multiple pathways.
AKR7A5 has selective substrate specificity towards naphthoquinone derivatives, suggesting that the aldo-keto reductase could play an important role in metabolism of certain naphthoquinone derivatives.
structure and tissue-related expression of AFAR genes
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde.
AFB1 aldehyde reductase 1
, AFB1-AR 1
, SSA reductase
, aflatoxin B1 aldehyde reductase member 2
, aflatoxin beta1 aldehyde reductase
, aldoketoreductase 7
, succinic semialdehyde reductase