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AP3B1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Zusätzlich bieten wir Ihnen AP3B1 Proteine (3) und AP3B1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal AP3B1 Primary Antibody für WB - ABIN2778057
Kuwahara, Inoue, DAgati, Fujimoto, Eguchi, Saha, Wolozin, Iwatsubo, Abeliovich: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. in Scientific reports 2016
point mutation c.2702C>G in exon 23 of the AP3B1 gene caused deletion of 112 bp in the mRNA in two siblings. This mutation activates a cryptic donor splice site that overrules the wild-type donor splice site of this exon. Three other novel mutations in AP3B1 were identified, that is, a nonsense mutation c.716G>A (p.Trp239Ter), a 1-bp and a 4-bp deletion c.177delA and c.1839_1842delTAGA, respectively
Synergistic defects of UNC13D and AP3B1 leading to adult hemophagocytic lymphohistiocytosis.
Using a co-affinity purification strategy, authors have identified the beta subunit of the AP-3 adapter protein complex, AP3B1, as a binding partner for the M proteins of the zoonotic paramyxoviruses Nipah virus and Hendra virus.
Data indicate that RUN and FYVE domain protein Rabip4'(RUFY1) interacts specifically and directly with adaptor protein complex AP-3.
The study provides a description of two unrelated individuals with Hermansky Pudlak syndrome type 2 associated with novel mutations in AP3B1.
diphosphoinositol pentakisphosphate-mediated pyrophosphorylation of AP3B1 modulates the interaction with Kif3A and, as a consequence, affects the release of HIV-1 virus-like particles.
Two nonsense mutations in ADTB3A, C1578T (R-->X) and G2028T (E-->X), result in lack of ADTB3A mRNA and beta3A protein production and a severe, G-CSF-responsive neutropenia in addition to oculocutaneous albinism and platelet storage pool deficiency.
Description of mutations in HPS genes that cause Hermansky-Pudlak syndrome (review)
We defined a homozygous genomic deletion in AP3B1, the gene encoding the beta chain of the adaptor protein-3 (AP-3) complex. The mutation leads to in-frame skipping of exon 15 and thus perturbs proper assembly of the heterotetrameric AP-3 complex.
A novel homozygous mutation in AP3B1 was detected in a 2-year-old patient with oculocutaneous albinism and immunodeficiency with Hermansky-Pudlak syndrome type II and eventual acute fatal hemophagocytic lymphohistiocytosis.
Mutations in AP3B1 is not associated with familial hemophagocytic lymphohistiocytosis
AP-1 and AP-3 are involved in the formation of distinct types of clathrin-coated vesicles, each of which is characterized by the incorporation of specific cargo membrane proteins
Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts.
HIV-2 particle release was dependent on the adaptor protein complex AP-3 and the newly identified AP-5 complex, but much less so on AP-1.
Data show that cytokine activation as a result of toll-like receptor 2 (TLR2) stimulation occurs at different intracellular locations and is mediated by the phagosomal trafficking molecule adaptor protein-3 (AP-3).
has a minimal impact on protective anti-cytomegalovirus responses
Our study indicates that Ap3b1 gene play distinct roles in melanin production and tyrosinase distribution compared with Hps1 gene.
we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway.
Data suggest functional links between OCA2 and the BLOC-1, BLOC-2, and AP-3 protein complexes involved in melanosome biogenesis.
The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2 are essential for plasmacytoid dendritic cells signaling through TLR7 and TLR9.
TLR9 signals leading to activation of IFN I, require TLR9 trafficking from endosomes to lysosome-related organelle; adapter protein-3 identified as protein complex responsible for trafficking of TLR9 to this subcellular compartment
AP-3 mediates the intracellular trafficking of CD1d to lysosomes for sampling of lipid antigens (Ags) involved in self-Ag presentation and thymocyte-positive selection.
AP-3 requirement is a particular attribute of the CD1d pathway in mice and that, although MHC class II molecules and CD1d are both found in late endosomes or lysosomes, different pathways mediate their intracellular trafficking
AP-3B plays a critical role in the normal formation and function of a subset of synaptic vesicles
the functions of beta3A- and beta3B-containing complexes are distinct and divergent in brain
WNK4 inhibits NCC activity by diverting the cotransporter to the lysosome for degradation by way of an AP-3 transport carrier
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene.
adaptor-related protein complex 3, beta 1 subunit
, AP-3 complex subunit beta-1
, adaptor-related protein complex 3, beta-1 subunit
, AP-3 complex subunit beta-1-like
, AP-3 complex beta-3A subunit
, adaptor protein complex AP-3 subunit beta-1
, clathrin assembly protein complex 3 beta-1 large chain
, adapter-related protein complex 3 subunit beta-1
, adaptor protein complex AP-3 beta-1 subunit
, adaptor-related protein complex AP-3, beta 1 subunit
, recombination induced mutation 2
, adaptor-related protein complex AP3 beta 1 subunit