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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways.
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Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT (zeige ITK Proteine) via Akt2 (zeige AKT2 Proteine) phosphorylation.
APPL1 positively mediated leptin (zeige LEP Proteine) signaling.
Decreased expression of APPL1 is associated with polycystic ovary syndrome.
Results indicate that persistent rab5 (zeige RAB5A Proteine) overactivation through beta-cleaved carboxy-terminal fragment of APP (zeige APP Proteine)-APPL1 interactions constitutes a novel APP (zeige APP Proteine)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (zeige RAB5A Proteine)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (zeige TLR3 Proteine)/4-dependent TBK1 (zeige TBK1 Proteine) and IKKepsilon (zeige IKBKE Proteine) activation in macrophages.
APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (zeige PRKCZ Proteine), as well as its functional interaction with both PP2A (zeige PPP2R2B Proteine) and myosin IIa.
APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.
Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (zeige TLR4 Proteine)-induced signaling, transcription, and cytokine secretion.
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (zeige HGF Proteine)-induced Akt (zeige AKT1 Proteine) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (zeige PRKAA1 Proteine) signaling.
APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (zeige INS Proteine) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (zeige INS Proteine) resistance and improves adipoR1 (zeige ADIPOR1 Proteine)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like