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ALCAM encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. Zusätzlich bieten wir Ihnen CD166 Antikörper (306) und CD166 Kits (74) und viele weitere Produktgruppen zu diesem Protein an.
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Human CD166 Protein expressed in Wheat germ - ABIN1344804
Delgado, Nugnes, Colombo, Troncoso, Fernández, Malchiodi, Frahm, Croci, Compagno, Rabinovich, Wolfenstein-Todel, Elola: Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011
Mouse (Murine) CD166 Protein expressed in Human Cells - ABIN2007131
Bowen, Patel, Li, Modrell, Malacko, Wang, Marquardt, Neubauer, Pesando, Francke: Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. in The Journal of experimental medicine 1995
Show all 5 Pubmed References
Alcama mediates Edn1 (zeige EDN1 Proteine) signaling during zebrafish cartilage morphogenesis.
The cell-adhesion molecule (zeige MCAM Proteine) Alcam is required for proper nephrogenesis and functions downstream of Fzd3 (zeige FZD3 Proteine) during embryonic kidney development.
No significant association between ALCAM expression and survival data was observed for all tumors
These data indicate that cardiac surgery influences the expression of CD162 (zeige SELPLG Proteine), CD166 and CD195 and that the intensity of the immune system response, displayed as the change in the CD162 (zeige SELPLG Proteine), CD166, CD195 expression, varies, depending on the surgical technique used.
These findings indicate that high ALCAM expression is associated with poor prognosis and advanced clinicopathological characteristics in CRC (zeige CALR Proteine) patients.
ALCAM is a potential mediator in the late complications of diabetes in the kidney.
we show that although the histological detection of ALCAM within the tumor tissue correlates strongly with tumor stage in BCa (zeige BLNK Proteine) (Figure (Figure2),2), it does not appear to be prognostic of overall survival. In contrast, urine ALCAM correlates with tumor stage and is a significant independent predictor of 3-year overall survival for patients after cystectomy.
Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms. A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells
CD166 functions as a risk factor for cancers, and the alterations of its different functional isoforms were observed to correlate with specific or interplayed clinical outcomes.
The results highlight the potential of ALCAM as a recurrent biomarker in early-stage endometrioid endometrial cancer and point to ALCAM as an important molecule in endometrial cancer dissemination by regulating cell migration, invasion, and metastasis.
MiR (zeige MLXIP Proteine)-148a and miR (zeige MLXIP Proteine)-152 can sensitize tamoxifen-resistant MCF-7 breast cancer cells to tamoxifen via downregulating ALCAM.
CHIP directly regulates the stability of CD166 protein through the ubiquitin proteasome system.
ALCAM is overexpressed on the surface of Human T-lymphotropic virus type 1-infected lymphocytes, both in chronically infected cell lines and in primary infected CD4 (zeige CD4 Proteine)(+) T lymphocytes.
Our data demonstrate that ALCAM KO mice develop a more severe active experimental autoimmune encephalomyelitis, which can be explained by an increased permeability of their BBB. This loss in BBB integrity is due to a dysregulation of junctional molecules caused by the lack of ALCAM at the level of the TJ molecules.
demonstrates for the first time the in vivo contribution of ALCAM to angiogenesis and reveals a novel role of stromally expressed ALCAM in supporting tumor growth and metastatic spread
Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers
Data indicate that the CD166/AKT (zeige AKT1 Proteine) axis modulates tumorigenesis via promotion of phosphorylation and facilitation of degradation, ubiquitination and cytosolic accumulation of FOXO (zeige FOXO3 Proteine) proteins in liver cancer cells.
ALCAM stably interacts with actin by binding to syntenin-1 (zeige SDCBP Proteine) and ezrin (zeige EZR Proteine).
CD166/ALCAM (ALCAM) is a close structural and functional homolog of RAGE (zeige AGER Proteine); it shows that binding of S100B (zeige S100B Proteine) to CD166/ALCAM induces dose- and time-dependent expression of NF-kappaB (zeige NFKB1 Proteine) family members in wild type and RAGE (zeige AGER Proteine)-deficient mouse endothelial cells.
Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166 expression on osteoblasts is directly correlated with Runx2 (zeige RUNX2 Proteine) expression and high hematopoiesis enhancing activity.
Behavioral deficits caused by prolonged IFN alpha (zeige IFNA Proteine) treatment were not prevented by blocking ALCAM, which is involved in immune cell entry to the brain.
novel role for ALCAM in stabilizing LEC-LEC interactions and in the organization and function of the LV network.
The presence of CD166 on prostate stem/progenitors and castration resistant sub-populations suggest that it is a cell surface molecule with the potential for targeted delivery of human prostate cancer therapeutics.
ALCAM up-regulation by hypercholesterolemia suggests a side-specific spatial role in the recruitment of leukocytes to aortic valve sclerosis sites.
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
CD166 antigen homolog A
, DM-GRASP homolog
, zn5 / zn-5 antigen
, zn8 / zn-8 antigen
, activated leukocyte cell adhesion molecule
, CD166 antigen
, DM-GRASP II
, CD166 antigen-like
, CD166 antigen homolog
, SB-10 antigen
, activated leucocyte cell adhesion molecule
, BEN glycoprotein
, SC1 glycoprotein