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The protein encoded by ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Zusätzlich bieten wir Ihnen Actin-Like 7A Antikörper (52) und Actin-Like 7A Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Anti-ACTL7a antibodies may cause infertility in mice because the in vitro treatment of mouse spermatozoa with ACTL7a antibody-containing serum markedly reduced the fertilizing potential of the spermatozoa.
Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
ACTL7a is an essential component of capacitation in mouse spermatozoa.
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
, actin-like 7-alpha
, actin-like protein 7A
, actin-like Tact2
, t-actin 2
, testis-specific actin-2