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ATRIP encodes an essential component of the DNA damage checkpoint. Zusätzlich bieten wir Ihnen ATRIP Kits (4) und ATRIP Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ATRIP Primary Antibody für IP, WB - ABIN151823
Choi, Lindsey-Boltz, Sancar: Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. in Proceedings of the National Academy of Sciences of the United States of America 2007
ATRIP must associate with ATR (zeige ATR Antikörper) in order for ATR (zeige ATR Antikörper) to carry out the phosphorylation of Chk1 (zeige CHEK1 Antikörper) effectively
Data show that recombinant TopBP1 (zeige TOPBP1 Antikörper) induces a large increase in the kinase activity of both Xenopus and human ATR (zeige ATR Antikörper)-ATRIP.
ATRIP deacetylation by SIRT2 promotes ATR-ATRIP binding to replication protein A-single-stranded DNA to drive ATR activation and thus facilitate recovery from replication stress.
ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway
Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with ATRIP and BAAT1 (zeige C7orf27 Antikörper) with preferences for specific side chains; in ATRIP, phospho-Ser239 and Phe242 are the main interacting residues.
Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia.
our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR (zeige ANTXR1 Antikörper)-ATRIP Seckel Syndrome to be defined
as an ATR (zeige ANTXR1 Antikörper)-associated kinase, Nek1 (zeige NEK1 Antikörper) enhances the stability and activity of ATR (zeige ANTXR1 Antikörper)-ATRIP before DNA damage, priming ATR (zeige ANTXR1 Antikörper)-ATRIP for a robust DNA damage response
ATRIP may function outside the context of the canonical ATR damage signaling pathway during HSV-1 infection to participate in the viral life cycle.
data suggest that RPA (zeige RPA1 Antikörper)-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR (zeige ANTXR1 Antikörper)-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling
there are at least two in vitro ATR-ATRIP DNA binding complexes, one which binds DNA with high affinity in an RPA-dependent manner and a second, which binds DNA with lower affinity in an RPA-independent manner
Collectively, our results suggest that the ATR (zeige ANTXR1 Antikörper)-mediated phosphorylation of ATRIP at Ser (zeige SIGLEC1 Antikörper)-68 and -72 is dispensable for the initial response to DNA damage.
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
, three prime repair exonuclease 1
, ATR interacting protein
, ATR-interacting protein-like
, mutagen sensitive 304
, ATM and Rad3-related-interacting protein
, ATM and Rad3 related interacting protein