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ATPIF1 encodes a mitochondrial ATPase inhibitor.
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Human Polyclonal ATPase Inhibitory Factor 1 Primary Antibody für ICC, IF - ABIN4282372
Kampf, Bergman, Oksvold, Asplund, Navani, Wiking, Lundberg, Uhlén, Ponten: A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas. in BMC medicine 2012
results suggest that IF1 overexpression promotes cancer cells survival under temporary anoxic conditions by preserving cellular ATP despite mitochondria dysfunction.
IF1 suppresses programmed cell death.
reverse phase protein microarrays identified the glycolysis promoting PKM2 (zeige PKM2 Antikörper) and IF1 proteins as specific biomarkers of dermatomyositis.
CF6 (zeige ATP5J Antikörper)-induced increase in apoptotic cells was blocked by immature or mature IF1, being accompanied by protein kinase B (PKB (zeige AKT1 Antikörper)) phosphorylation. IF1 antagonizes the pro-apoptotic action of CF6 (zeige ATP5J Antikörper) by relief of intracellular acidification and resultant phosphorylation of PKB (zeige AKT1 Antikörper).
The potential role of mitochondrial ATPIF1 in coronary heart disease was reviewed.
this study shows that abnormal expression of ATPase (zeige DNAH8 Antikörper) inhibitor, mitochondrial isoform 1 precursor(IF1) may relate to the hyperfunction of immune responses and excessive apoptosis of severe aplastic anemia CD34 (zeige CD34 Antikörper)(+) cells
These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience
Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1 (zeige HIF1A Antikörper)).
Upon IF1 interaction with the ATP synthase both the synthetic and hydrolytic activities of the engine of oxidative phosphorylation are inhibited. (Review)
PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.
The intrinsically disordered inhibitory region of IF1 interacts first with the alphaEbetaE-catalytic interface, the most open of the three catalytic interfaces, where the available interactions with the enzyme allow it to form an alpha-helix from residues 31-49.
The N-terminal region of IF(1) destabilizes the interaction of the inhibitor with F(1)-ATPase (zeige DNAH8 Antikörper) and may assist in removing the inhibitor from its binding site when F(1)F(o)-ATPase is (zeige ATP11A Antikörper) making ATP
in addition to His49, Glu26 participates in pH sensing in bovine IF(1), and the mechanism of pH sensing mediated by Glu26 is different from the dimer-tetramer model proposed previously
Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1 (zeige SETD2 Antikörper)).
induces VEGF (zeige VEGFA Antikörper) expression and promotes xenograft tumor-induced angiogenesis
IF1 is not an essential protein for mice despite its ubiquitous presence in eukaryotes.
methionine deprivation results in an antioxidant response that includes an increase in the levels of HSPA1A (zeige HSPA1A Antikörper) and DNAJB1 (zeige DNAJB1 Antikörper) mRNA
the identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development
Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis.
The study reveals that IEX-1 (zeige IER3 Antikörper) targets the mitochondrial F1Fo-ATPase (zeige DNAH8 Antikörper) Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS (zeige ROS1 Antikörper) production.
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.
ATP synthase inhibitor protein
, ATPase inhibitor protein
, ATPase inhibitor, mitochondrial
, inhibitor of F(1)F(o)-ATPase
, ATPase inhibitory factor 1
, mitochondrial ATPIF1
, ATPase inhibitor (rat mitochondrial IF1 protein)
, ATPase inhibitor A, mitochondrial
, inhibitor of F(1)F(o)-ATPase A
, protein pinotage
, Inhibitor of F(1)F(o)-ATPase
, ATP synthase CF0 A subunit