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The protein encoded by ABCC10 is a member of the superfamily of ATP-binding cassette (ABC) transporters.
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FOXM1 (zeige FOXM1 ELISA Kits) promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells.
It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation.
The present study shows that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients
BAG3 (zeige BAG3 ELISA Kits)-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance.
the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10
ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays.
This report describes the ATPase (zeige DNAH8 ELISA Kits) activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase (zeige TXK ELISA Kits) sorafenib as an inhibitor of ABCC10.
Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model.
Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B.
This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro.
Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 (zeige EIF2C2 ELISA Kits) complex.
Abcc10 is dispensable for health and viability and it is an endogenous resistance factor for taxanes, other natural product agents, and nucleoside analogues
MDR1 (zeige ABCB4 ELISA Kits) expression, MRP1 (zeige ABCC1 ELISA Kits) expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.
ATP-binding cassette sub-family C member 10
, multidrug resistance-associated protein 7
, ATP-binding cassette, sub-family C (CFTR/MRP), member 10
, oocyte maturation 1
, ran-binding protein 8
, ATP-binding cassette, subfamily C (CFTR/MRP), member 10