anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Antikörper

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human ABCC1 ABCC1 4363 P33527
Anti-Maus ABCC1 ABCC1 17250 O35379
Anti-Ratte ABCC1 ABCC1 24565 Q8CG09
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Top anti-ABCC1 Antikörper auf antikoerper-online.de

Showing 10 out of 127 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-ABCC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Lung 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-MRP1 antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: A549 Cell Lysate Anti-MRP1 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Ziege Unkonjugiert ELISA, WB EB08734 (0.05µg/ml) staining of A549 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Western blot analysis of MRP expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Ratte Unkonjugiert IHC (fro), IF, IHC (p), WB   1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$544.50
Details
Human Kaninchen Unkonjugiert FACS, WB Western blot analysis of ABCC1 antibody (C-term) (ABIN390525) in Ramos cell line lysates (35 µg/lane). ABCC1 (arrow) was detected using the purified polyclonal antibody. Flow cytometric analysis of NCI-H292 cells using ABCC1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IHC (fro), IF, IHC (p), WB   1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$544.50
Details
Human Maus Fluorescein FACS Detection of MRP1 in H69AR Human Cell Line by Flow Cytometry. H69AR human small cell lung cancer cell line was stained with Mouse Anti-Human MRP1 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Anmelden zum Anzeigen 8 bis 9 Tage
$281.75
Details
Human Maus PE FACS Detection of MRP1 in H69AR Human Cell Line by Flow Cytometry. H69AR human small cell lung cancer cell line was stained with Mouse Anti-Human MRP1 PE-conjugated Monoclonal Antibody. 100 Tests Anmelden zum Anzeigen 8 bis 9 Tage
$351.90
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

Am meisten referenzierte anti-ABCC1 Antikörper

  1. Human Polyclonal ABCC1 Primary Antibody für IHC (p), WB - ABIN3044230 : Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. in Asian Pacific journal of cancer prevention : APJCP 2013 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ABCC1 Primary Antibody für CyTOF, FACS - ABIN4900819 : Fiskus, Rao, Fernandez, Herger, Yang, Chen, Kolhe, Mandawat, Wang, Joshi, Eaton, Lee, Atadja, Peiper, Bhalla: Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. in Blood 2008 (PubMed)

  3. Monoclonal ABCC1 Primary Antibody für IF, WB - ABIN534097 : Chen, Yang, Li, Zhang: The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function. in The Journal of biological chemistry 2006 (PubMed)

  4. Human Monoclonal ABCC1 Primary Antibody für FACS - ABIN4898742 : Keshet, Goldstein, Itzhaki, Cesarkas, Shenhav, Yakirevitch, Treves, Schachter, Amariglio, Rechavi: MDR1 expression identifies human melanoma stem cells. in Biochemical and biophysical research communications 2008 (PubMed)

  5. Human Monoclonal ABCC1 Primary Antibody für FACS - ABIN4898743 : Takahashi, Shibata, Oba, Ishikawa, Yoshikawa, Tatsunami, Takahashi, Tampo: Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. in Life sciences 2009 (PubMed)

Weitere Antikörper gegen ABCC1 Interaktionspartner

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. Enhanced BRAF (zeige BRAF Antikörper)-mediated NRF2 (zeige GABPA Antikörper) gene transcription and Histone Acetyltransferases-mediated NRF2 (zeige GABPA Antikörper) protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II (zeige TOP2 Antikörper) poison-resistant cancer cells.

  2. Pomolic acid also down-modulated the activity of the multidrug resistance associated protein 1 (MRP1) and inhibited migration of Glioblastoma (GBM) cells. These results show that PA acts on several pathways of GBM drug resistance and therefore may be of potential interest for the treatment of this tumor

  3. Our data present for the very first time the high negative correlation between MRP1 (zeige MDM4 Antikörper) protein expression in LSC (zeige ARHGEF1 Antikörper) and AML (zeige RUNX1 Antikörper) patients' remission. It does strongly suggest that MRP1 (zeige MDM4 Antikörper) expression in LSC (zeige ARHGEF1 Antikörper) is an adverse prognostic marker in patients with de novo AML (zeige RUNX1 Antikörper).

  4. These data showed that Wls (zeige WLS Antikörper) was differentially expressed in HCC (zeige FAM126A Antikörper). Statistical analysis results suggest that Wls (zeige WLS Antikörper) expression might increase as HCC (zeige FAM126A Antikörper) progresses.

  5. No significant correlation was observed between rs504348 genotypes and cystic fibrosis (zeige S100A8 Antikörper) severity. A significantly higher expression of ABCC1 mRNA was induced by CF plasma compared to healthy control plasma.

  6. MRP1 (zeige MDM4 Antikörper) is regulated by CLIC1 (zeige CLIC1 Antikörper), leading to CLIC1 (zeige CLIC1 Antikörper)-mediated development of chemoresistance in choriocarcinoma cells.

  7. Wls (zeige WLS Antikörper)-SEC12 (zeige PREB Antikörper) binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls (zeige WLS Antikörper) that fails to communicate with the COPII machinery cannot effectively support Wnt (zeige WNT2 Antikörper) secretion. These data suggest that formation of early Wnt (zeige WNT2 Antikörper) secretory vesicles is carefully regulated to ensure proper export of functional ligands

  8. High MRP1 (zeige MDM4 Antikörper) expression is associated with resistance to doxorubicin in breast cancer.

  9. Our data indicates that hypomethylation of the ABCC1 promoter is not cancer type-specific but occurs in cancer cell lines of different origins.

  10. Our work demonstrates for the first time that the adaptation to endoplasmic reticulum(ER) stress in cancer cells produces a MDR phenotype. The PERK (zeige EIF2AK3 Antikörper)/Nrf2 (zeige GABPA Antikörper)/MRP1 (zeige MDM4 Antikörper) axis is responsible for the resistance to ER stress and chemotherapy, and may represent a good therapeutic target in aggressive and resistant tumors.

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo (zeige C9orf3 Antikörper) form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.

  2. P-gp (zeige ABCB4 Antikörper), Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states.

  2. Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia.

  3. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  4. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.

  5. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  6. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (zeige TPM4 Antikörper) sertoli cell line.

  7. neprilysin (zeige MME Antikörper) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  8. Expression of apoA-I (zeige APOA1 Antikörper) or ABCA1 (zeige ABCA1 Antikörper) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis

  9. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.

  10. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (zeige ABCC2 Antikörper), in WT cells but not in metallothionein (zeige MT Antikörper)-null cells.

Rabbit ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. MRP1 appears to be primarily localized in the basolateral membrane of conjunctival epithelial cells and functions in the efflux of certain organic anions and inflammatory factors

ABCC1 Antigen-Profil

Protein Überblick

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Genbezeichner und Symbole assoziert mit ABCC1

  • ATP binding cassette subfamily C member 1 (ABCC1) Antikörper
  • wntless Wnt ligand secretion mediator (WLS) Antikörper
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1) Antikörper
  • ATP binding cassette subfamily C member 1 (Abcc1) Antikörper
  • multidrug resistance-associated protein 1 (LOC100152428) Antikörper
  • multidrug resistance-associated protein 1 (LOC100346553) Antikörper
  • ABC29 Antikörper
  • ABCC Antikörper
  • Abcc1a Antikörper
  • Abcc1b Antikörper
  • ABCC13 Antikörper
  • Avcc1a Antikörper
  • C1orf139 Antikörper
  • EVI Antikörper
  • GPR177 Antikörper
  • GS-X Antikörper
  • Mdrap Antikörper
  • mig-14 Antikörper
  • Mrp Antikörper
  • Mrp1 Antikörper

Bezeichner auf Proteinebene für ABCC1

ATP-binding cassette transporter variant ABCC1delta-ex13 , ATP-binding cassette transporter variant ABCC1delta-ex13&14 , ATP-binding cassette transporter variant ABCC1delta-ex25 , ATP-binding cassette transporter variant ABCC1delta-ex25&26 , LTC4 transporter , leukotriene C(4) transporter , multidrug resistance-associated protein 1 , G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , ATP-binding cassette sub-family C member 1 , multidrug resistance protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1b , multiple drug resistance-associated protein , ATP-binding cassette sub-family C ( CFTR/MRP) member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1 , ATP-binding cassette superfamily member C1 , ATP-binding cassette transporter sub-family C member 1 , ATP-binding cassette, sub-family C, member 1 , multiple drug resistance protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 13

GENE ID SPEZIES
4363 Homo sapiens
79971 Homo sapiens
281588 Bos taurus
395416 Gallus gallus
403453 Canis lupus familiaris
17250 Mus musculus
24565 Rattus norvegicus
100734674 Cavia porcellus
733619 Sus scrofa
791240 Equus caballus
100345841 Oryctolagus cuniculus
100152428 Sus scrofa
100346553 Oryctolagus cuniculus
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