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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Zusätzlich bieten wir Ihnen ATG4B Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ATG4B Primary Antibody für IF, IHC (p) - ABIN1882065
Pontén, Westermark: Properties of human malignant glioma cells in vitro. in Medical biology 1978
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Human Polyclonal ATG4B Primary Antibody für WB - ABIN1881082
Kabeya, Mizushima, Yamamoto, Oshitani-Okamoto, Ohsumi, Yoshimori: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. in Journal of cell science 2004
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Human Polyclonal ATG4B Primary Antibody für IHC (p), WB - ABIN388494
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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These results support the conclusion that CML24 affects autophagy progression through interactions with ATG4.
AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. [ATG4b]
ATG4B contains a C-terminal LIR (zeige CD300C Antikörper) motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 (zeige GABARAPL2 Antikörper)
O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition
these results demonstrate a novel association of ATG4B positive expression with HER2 (zeige ERBB2 Antikörper) positive breast cancers
Knockdown of ATG4B had only a minor effect on AMPK (zeige PRKAA1 Antikörper) activation and G1 phase arrest in liver kinase B1 (zeige STK11 Antikörper)-deficient or AMPK (zeige PRKAA1 Antikörper)-inhibited cancer cells.
Our work describes an MST4 (zeige MST4 Antikörper)-ATG4B signaling axis that influences glioblastoma autophagy and malignancy
Data show that ULK1 (zeige ULK1 Antikörper), a protein kinase (zeige CDK7 Antikörper) activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316.
Reporter assay showed that HSF1 (zeige HSF1 Antikörper) increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 (zeige HSF1 Antikörper) bound to the site (-1429 to -1417) in ATG4B gene promoter region.
The structure and regulatory machinery of Atg4b [review]
MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia.
The results have interesting implications that SLC27A4 (zeige SLC27A4 Antikörper)/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application.
At the microtubule-actin crossover junction, ATG4B detaches LC3B (zeige MAP1LC3B Antikörper) from melanosomal membranes by enzymatic delipidation.
ATG4B contains a C-terminal LIR (zeige CD300C Antikörper) motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 (zeige MAP1LC3B Antikörper)
miR (zeige MLXIP Antikörper)-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs.
the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis
REDD1 (zeige DDIT4 Antikörper)/TXNIP (zeige TXNIP Antikörper) complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy.
these findings demonstrate a role for Ser (zeige SIGLEC1 Antikörper)-383 and Ser (zeige SIGLEC1 Antikörper)-392 phosphorylation of ATG4B in control of autophagy.
mTOR (zeige FRAP1 Antikörper) inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux.
An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA (zeige CEBPB Antikörper) and is shown to play an important role in 3T3-L1 adipocyte differentiation.
the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 (zeige MAP1LC3A Antikörper) processing and autophagy.
The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ATG4 autophagy related 4 homolog B
, cysteine protease ATG4B
, autophagy 4b variant 1Cysteine protease ATG4B
, autophagy 4b variant 3
, cysteine protease ATG4b
, APG4 autophagy 4 homolog B
, autophagy-related protein 4 homolog B
, autophagy-related cysteine endopeptidase 2B
, AUT-like 1 cysteine endopeptidase
, autophagy-related cysteine endopeptidase 1
, APG4 (ATG4) autophagy-related homolog B
, AUT-like 1, cysteine endopeptidase
, autophagin 1
, autophagy-related 4B
, cysteine protease involved in autophagy APG4-B
, autophagy related 4 homolog B
, autophagy related 4-like protein B