APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) ELISA Kits

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Zusätzlich bieten wir Ihnen APEX2 Antikörper (52) und APEX2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
APEX2 27301 Q9UBZ4
APEX2 77622 Q68G58
Anti-Ratte APEX2 APEX2 317628  
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Top APEX2 ELISA Kits auf antikoerper-online.de

Showing 2 out of 2 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human
  96 Tests 15 bis 18 Tage
$875.60
Details
Maus
  96 Tests 15 bis 18 Tage
$875.60
Details

Weitere ELISA Kits für APEX2 Interaktionspartner

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. we describe the use of Clustered Regularly Interspaced Short Palindromic Repeats and an engineered ascorbate peroxidase 2 (APEX2) system to investigate local chromatin interactions (CAPLOCUS). We showed that with specific small-guide RNA targets, CAPLOCUS could efficiently identify both repetitive genomic regions and single-copy genomic locus with high resolution.

  2. Identified APEX2 and FEN1 as synthetic lethal genes with both BRCA1 and BRCA2 loss of function in tumor cell lines.

  3. Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.

  4. Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III

  5. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  6. Ape2 may be involved in repair of oxidative DNA damage and PCNA-dependent repair synthesis.

  7. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. APE2 promotes ATR-Chk1 DNA damage response pathway from a single-strand break.

  2. APE2 associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 signaling.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte transition, due to a p53-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1.

  5. may participate in postreplicative base excision repair

  6. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  7. Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  8. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  9. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Antigen-Profil

Beschreibung des Gens

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit APEX2

  • apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) Antikörper
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2) Antikörper
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) Antikörper
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L) Antikörper
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) Antikörper
  • apurinic/apyrimidinic endonuclease 2 (Apex2) Antikörper
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2) Antikörper
  • ape2 Antikörper
  • apexl2 Antikörper
  • C430040P13Rik Antikörper
  • xth2 Antikörper
  • zgc:55889 Antikörper

Bezeichner auf Proteinebene für APEX2

AP endonuclease 2 , AP endonuclease XTH2 , DNA-(apurinic or apyrimidinic site) lyase 2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like

GENE ID SPEZIES
27301 Homo sapiens
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
491499 Canis lupus familiaris
511790 Bos taurus
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
77622 Mus musculus
317628 Rattus norvegicus
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