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The protein encoded by ARFRP1 is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins.
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COUP-TFII is a critical factor controlling metastatic gene networks to promote prostate cancer metastasis.
fifth of COUP-TFI cells also co-expressed COUP-TFII, and cells expressing either transcription factor followed posterior or anterio-lateral pathways into the cortex
Results provide evidence that ARFRP1 is required for HCV propagation through its interaction with NS5A protein. Also, ARFRP1 is involved in the regulation of lipid droplet (LD) growth in HCV-infected cells and, recruits SNAP23 to sites in close proximity to LDs.
Dividing COUP-TFII+ progenitor cells were localized to ventral CGE
We showed that the orphan receptor COUP-TFII is an important player in hepatic neoangiogenesis. COUP-TFII expression in hepatic stellate cells (HSC) controls the crosstalk between hepatic HSC and endothelial cells coordinating vascular remodelling during liver injury.
Low COUPTFII expression is associated with prostate cancer.
ARFRP1 shifted from a predominantly cis-Golgi and endosome-to-trans-Golgi network localization to localizing both Golgi and non-Golgi vesicular structures in hNaa30-depleted cells.
We conclude that COUP-TFII mutations can cause diaphragmatic hernias, and should be included in the differential diagnosis of CDH (zeige CHDH ELISA Kits) patients, particularly those with comorbid congenital heart defects.
Studied the role of Nuclear receptor subfamily 2 group F member 2 (NR2F2) in MSC chondrogenesis in bioprinted cartilage. NR2F2 over-expressed MSCs showed significantly enhanced chondrogenesis while NR2F2 knockdown cells demonstrated the exactly opposite behavior.
NR2F2 is a Direct Target Gene of miR (zeige MLXIP ELISA Kits)-382 in colorectal cancer.
ARFRP1 and the Golgi apparatus play an important role in lipoprotein maturation in the liver.
The GTPase (zeige RACGAP1 ELISA Kits) ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 (zeige IGF1 ELISA Kits) secretion and GLUT2 (zeige SLC2A2 ELISA Kits) sorting and is thereby essential for normal growth and glycogen (zeige GYS1 ELISA Kits) storage
Arfrp1 appears to be involved in sorting of GLUT4 (zeige SLC2A4 ELISA Kits).
Lipid droplets of adipocytes of Arfrp1(-/-) mice were smaller and exhibited ultrastructural alterations, such as a disturbed interaction of small lipid particles with larger droplets.
ADP-ribosylation factor-like GTPase (zeige RACGAP1 ELISA Kits) ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin (zeige CDH1 ELISA Kits).
This study provides the first detailed analysis of the regional distribution of ARFRP1 in the mouse brain and a quantitative view of its changes following sleep deprivation.
These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi.
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.
ADP-ribosylation factor-related protein 1
, ARF-related protein 1
, SCG10 like-protein
, helicase-like protein NHL
, ADP-ribosylation factor related protein 1
, COUP transcription factor 2
, COUP transcription factor II
, apolipoprotein A-I regulatory protein 1
, apolipoprotein AI regulatory protein 1
, chicken ovalbumin upstream promoter transcription factor 2
, chicken ovalbumin upstream promoter-transcription factor I
, chicken ovalbumin upstream promoter-transcription factor II variant 1
, chicken ovalbumin upstream promoter-transcription factor II variant 2
, chicken ovalbumin upstream promoter-transcription factor II variant 3
, putative ADP-ribosylation factor related protein 1 variant 1