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ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Zusätzlich bieten wir Ihnen ADAMTS5 Antikörper (121) und ADAMTS5 Kits (43) und viele weitere Produktgruppen zu diesem Protein an.
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Energy expenditure and thermogenesis were not significantly different between KO and WT ADAMTS5-J mice (in contrast to somewhat enhanced levels in ADAMTS5-P mice). Insulin (zeige INS Proteine) sensitivity was improved in the ADAMTS5-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model
Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.
research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality
TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (zeige ACAN Proteine) and Vcan (zeige Vcan Proteine) by an ADAMTS (zeige ADAMTS1 Proteine) other than TS5.
Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (zeige ADAMTS4 Proteine) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.
aggrecan (zeige ACAN Proteine) and brevican (zeige BCAN Proteine) proteolysis is compensated in Adamts4 (zeige ADAMTS4 Proteine)-/- or Adamts5-/- mice by ADAMTS (zeige ADAMTS1 Proteine) proteoglycanase (zeige MMP3 Proteine) family members but a threshold of versican (zeige Vcan Proteine) proteolysis is sensitive to the loss of a single ADAMTS (zeige ADAMTS1 Proteine) proteoglycanase (zeige MMP3 Proteine) during spinal cord injury
The present study reveals ADAMT-5 expression by mast cells(MCs (zeige SMCP Proteine)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.
Western blot analyses indicated that aggrecanase (zeige ADAMTS4 Proteine)-generated proteoglycan (zeige Vcan Proteine) fragments are produced after SCI.
RelA/p65 (zeige NFkBP65 Proteine) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.
Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.
Data suggest that 3prime untranslated region of ADAMTS5 mRNA contains 'seedmatched-sequence' for hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-140-3p (microRNA-140-3p); in chondrocytes from articular cartilage of patients with knee osteoarthritis, interleukin-1beta up-regulates expression of ADAMTS5 and down-regulates expression of hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-140-3p. (ADAMTS5 = ADAM metallopeptidase with thrombospondin type 1 motif 5 A)
A novel genetic variant in ADAMTS5 is associated with bicuspid aortic valve disease.
expression by synovial cells induced by hemoglobin at low doses, suggesting a possible role for hemoglobin in cartilage damage after intra-articular hemorrhage
The SNPs rs1337185 in COL11A1 (zeige COL11A1 Proteine) and rs162509 in ADAMTS5 are associated with susceptibility to lumbar disc degeneration. The C allele of rs1337185 is risky for patients who are affected by lumbar pathologies such as disc herniation, stenosis and spondylolisthesis. The G allele of rs16250 represents a risk factor for the development of disc herniation.
ADAMTS5 is hypermethylated and inhibits cancer cells invasion and migration in colorectal cancer, and correlates with OS and DFS (zeige FST Proteine).
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1 (zeige LRP1 Proteine).
MMP-13 (zeige MMP13 Proteine) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (zeige LRP1 Proteine) is a key modulator of extracellular levels of MMP-13 (zeige MMP13 Proteine) and its internalization is independent of the levels of ADAMTS-4 (zeige ADAMTS4 Proteine), -5 and TIMP-3 (zeige TIMP3 Proteine).
The IL1B (zeige IL1B Proteine)/AP-1 (zeige FOSB Proteine)/miR (zeige MLXIP Proteine)-30a/ADAMTS-5 axis regulates cartilage matrix degradation in osteoarthritis.
The findings suggest that miR (zeige MLXIP Proteine)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5 (zeige IGFBP5 Proteine).
Results provide direct evidence indicating that Fibulin-2 (zeige FBLN2 Proteine) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (zeige FBLN2 Proteine) and the ADAMTSs metalloproteases.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (zeige ADAMTS4 Proteine)) explains the minor contribution of the MMP enzymes to aggrecan (zeige ACAN Proteine) catabolism in vivo.
ADAMTS4 (zeige ADAMTS4 Proteine) and ADAMTS5 are inhibited by alpha2-macroglobulin (zeige A2M Proteine)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (zeige ADAMTS4 Proteine) and ADAMTS-5
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
ADAM metallopeptidase with thrombospondin type 1 motif, 5
, a disintegrin and metalloproteinase with thrombospondin motifs 5-like
, A disintegrin and metalloproteinase with thrombospondin motifs 5
, ADAM-TS 5
, a disintegrin and metalloproteinase with thrombospondin motifs 11
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)