ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 Proteine (ADAMTS7)

The protein encoded by ADAMTS7 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Zusätzlich bieten wir Ihnen ADAMTS7 Antikörper (59) und ADAMTS7 Kits (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ADAMTS7 108153  
ADAMTS7 11173 Q9UKP4
ADAMTS7 315879 Q1EHB3
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
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Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$720.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$640.00
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ADAMTS7 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , ,
,
Rat (Rattus)

Weitere Proteine zu ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 (ADAMTS7) Interaktionspartnern

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 (ADAMTS7) Interaktionspartner

  1. Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis.

  2. Mice lacking Adamts7, Ldlr, Apoe had less lesion formation in aortas and aortic roots vs controls and less neointimal formation after femoral wire injury. Adamts7 expression was induced by injury and hyperlipidemia.

  3. Adamts-7 deficiency substantially ameliorated neointima formation in mice at days 14 and 28 after injury. ADAMTS-7 inhibited both endothelial cell proliferation and migration.

  4. The overexpression of ADATMTS-7 might contribute to early inflammatory kidney damage associated with aging

  5. ADAMTS-7 and TNF-alpha form a positive feedback loop in the regulation of cartilage degradation and osteoarthritis progression.

  6. ADAMTS7B has a domain organization with a total of eight thrombospondin type 1 repeats in its ancillary domain. Of these, seven are arranged in two distinct clusters that are separated by a mucin domain

  7. Findings demonstrate that ADAMTS-7, a direct target of PTHrP signaling, negatively regulates endochondral bone formation by associating with and inactivating GEP chondrogenic growth factor.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 (ADAMTS7) Interaktionspartner

  1. data show that ADAMTS-7 is associated with a vulnerable plaque phenotype in human carotid lesions. These data support previous observations of a potential proatherogenic role of ADAMTS-7.

  2. Multivariate analysis showed that DeltaADAMTS-7(day 7 minus day 1) was independently associated with left ventricular reverse remodeling

  3. Genetic variation at the ADAMTS7 locus is associated with reduced severity of coronary artery disease.

  4. Studied gene expression of genetic variants of ADAMTS7 in atherosclerotic occlusive peripheral arterial disease (PAD). Found mRNA levels of ADAMTS7 to be significantly higher in PAD patients than controls, and that the rs1994016 CC and rs3825807 TT genotypes may upregulate ADAMTS7 mRNA levels and may influence PAD development.

  5. The findings suggest that upregulation of ADAMTS-7 and down regulation of COMP are associated with human AA.

  6. The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events.

  7. miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage.

  8. Allelic variation that associates with reduced ADAMTS7 expression confers stronger coronary heart disease protection in never-smokers than in ever-smokers.

  9. During inflammatory conditions, AP-1 and Sp1 sustained the expression of ADAMTS7, and ADAMTS7 sustained the expression of catabolic genes in nucleus pulposus cells

  10. ADAMTS7 and LPA single nucleotide polymorphisms are related to a 24-h ambulatory systolic-diastolic pressure regression index.

  11. Expression of miR-26a and miR-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.

  12. Our results indicate the presence of ADAMTS-7 in human NP cells and imply its potential role in disc degeneration.

  13. The main contribution of this study is the proposal of a pharmacophore for ADAMTS7.

  14. The significant associations observed between this coding variant in ADAMTS7 and the risk of CAD development.

  15. Logistic regression analysis indicated that the association between ADAMTS-7 and heart failure after AMI was independent from traditional cardiovascular risk factors and other biomarkers

  16. Data conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-alpha and Phospho-NF-kappaB P65 in cartilage, which may imply its association with cartilage destruction of ONFH.

  17. ADAMTS7 localized to cells having smooth muscle cell markers in human coronary artery disease lesions. Cultured vascular smooth muscle cells had ADAMTS7 at the cytoplasm and cell membrane, where it colocalized with markers of podosomes.

  18. There was a reduction in the amount of cleaved ADAMTS7 prodomain in media conditioned by VSMCs of the G/G genotype.

  19. statistically significant increase in mRNA expression of ADAMTS-7 and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs

  20. identified ADAMTS7 as novel locus for CAD and association of ABO with MI in the presence of CAD

ADAMTS7 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs.

Genbezeichner und Symbole assoziert mit ADAMTS7

  • ADAM metallopeptidase with thrombospondin type 1 motif 7 (ADAMTS7)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 (Adamts7)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 7 (Adamts7)
  • ADAM metallopeptidase with thrombospondin type 1 motif 7 (Adamts7)
  • ADAM-TS7 Protein
  • ADAM-TS 7 Protein
  • ADAMTS-7 Protein
  • ADAMTS7B Protein
  • COMPase Protein

Bezeichner auf Proteinebene für ADAMTS7

ADAM metallopeptidase with thrombospondin type 1 motif, 7 , A disintegrin and metalloproteinase with thrombospondin motifs 7 , ADAM-TS 7 , ADAMTS-7 , COMPase , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 , metalloprotease , a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein , ADAM-TS7 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7

GENE ID SPEZIES
100026396 Monodelphis domestica
108153 Mus musculus
11173 Homo sapiens
100340872 Oryctolagus cuniculus
315879 Rattus norvegicus
504694 Bos taurus
100728771 Cavia porcellus
100154398 Sus scrofa
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