ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 Proteine (ADAMTS7)

The protein encoded by ADAMTS7 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Zusätzlich bieten wir Ihnen ADAMTS7 Antikörper (60) und ADAMTS7 Kits (26) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ADAMTS7 108153  
ADAMTS7 11173 Q9UKP4
ADAMTS7 315879 Q1EHB3
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
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Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$720.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$640.00
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ADAMTS7 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , ,
,
Rat (Rattus)

Weitere Proteine zu ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 (ADAMTS7) Interaktionspartnern

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 (ADAMTS7) Interaktionspartner

  1. Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis.

  2. Mice lacking Adamts7, Ldlr, Apoe had less lesion formation in aortas and aortic roots vs controls and less neointimal formation after femoral wire injury. Adamts7 expression was induced by injury and hyperlipidemia.

  3. Adamts-7 deficiency substantially ameliorated neointima formation in mice at days 14 and 28 after injury. ADAMTS-7 inhibited both endothelial cell proliferation and migration.

  4. ADAMTS-7 and TNF-alpha (zeige TNF Proteine) form a positive feedback loop in the regulation of cartilage degradation and osteoarthritis progression.

  5. ADAMTS7B has a domain organization with a total of eight thrombospondin type 1 repeats in its ancillary domain. Of these, seven are arranged in two distinct clusters that are separated by a mucin (zeige SLC13A2 Proteine) domain

  6. Findings demonstrate that ADAMTS-7, a direct target of PTHrP signaling, negatively regulates endochondral bone formation by associating with and inactivating GEP (zeige GRN Proteine) chondrogenic growth factor.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 7 (ADAMTS7) Interaktionspartner

  1. Genetic variation at the ADAMTS7 locus is associated with reduced severity of coronary artery disease.

  2. Studied gene expression of genetic variants of ADAMTS7 in atherosclerotic occlusive peripheral arterial disease (PAD). Found mRNA levels of ADAMTS7 to be significantly higher in PAD patients than controls, and that the rs1994016 CC and rs3825807 TT genotypes may upregulate ADAMTS7 mRNA levels and may influence PAD development.

  3. The findings suggest that upregulation of ADAMTS-7 and down regulation of COMP (zeige COMP Proteine) are associated with human AA.

  4. The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events.

  5. miR (zeige MLXIP Proteine)-105/Runx2 (zeige RUNX2 Proteine) axis mediates FGF2 (zeige FGF2 Proteine)-induced ADAMTS (zeige ADAMTS13 Proteine) expression in osteoarthritis cartilage.

  6. Allelic variation that associates with reduced ADAMTS7 expression confers stronger coronary heart disease protection in never-smokers than in ever-smokers.

  7. During inflammatory conditions, AP-1 (zeige FOSB Proteine) and Sp1 (zeige PSG1 Proteine) sustained the expression of ADAMTS7, and ADAMTS7 sustained the expression of catabolic genes in nucleus pulposus cells

  8. ADAMTS7 and LPA single nucleotide polymorphisms are related to a 24-h ambulatory systolic-diastolic pressure regression index.

  9. Expression of miR (zeige MLXIP Proteine)-26a and miR (zeige MLXIP Proteine)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1 (zeige ATP1B1 Proteine), COL4A2 (zeige COL4a2 Proteine), CPEB3 (zeige CPEB3 Proteine), CDK6 (zeige CDK6 Proteine), DNMT3a (zeige DNMT3A Proteine) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.

  10. Our results indicate the presence of ADAMTS-7 in human NP cells and imply its potential role in disc degeneration.

ADAMTS7 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs.

Genbezeichner und Symbole assoziert mit ADAMTS7

  • ADAM metallopeptidase with thrombospondin type 1 motif 7 (ADAMTS7)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 (Adamts7)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 7 (Adamts7)
  • ADAM metallopeptidase with thrombospondin type 1 motif 7 (Adamts7)
  • ADAM-TS7 Protein
  • ADAM-TS 7 Protein
  • ADAMTS-7 Protein
  • ADAMTS7B Protein
  • COMPase Protein

Bezeichner auf Proteinebene für ADAMTS7

ADAM metallopeptidase with thrombospondin type 1 motif, 7 , A disintegrin and metalloproteinase with thrombospondin motifs 7 , ADAM-TS 7 , ADAMTS-7 , COMPase , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 , metalloprotease , a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein , ADAM-TS7 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7

GENE ID SPEZIES
100026396 Monodelphis domestica
108153 Mus musculus
11173 Homo sapiens
100340872 Oryctolagus cuniculus
315879 Rattus norvegicus
504694 Bos taurus
100728771 Cavia porcellus
100154398 Sus scrofa
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