ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 3 Proteine (ADAMTS3)

ADAMTS3 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.

alle Proteine anzeigen Gen GeneID UniProt
Human ADAMTS3 ADAMTS3 9508 O15072
Ratte ADAMTS3 ADAMTS3 305253  
Maus ADAMTS3 ADAMTS3 330119  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
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Weitere Proteine zu ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 3 (ADAMTS3) Interaktionspartnern

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 3 (ADAMTS3) Interaktionspartner

  1. Molecular cloning and in silico analysis identify potential transcription factor binding sites in the ADAMTS3 promoter region and show that SP1 (zeige PSG1 Proteine) downregulated ADAMTS3 transcriptional activity in osteosarcoma cell lines. As consistent with the transcriptional activity, mRNA, and protein expression levels were also decreased by SP1 (zeige PSG1 Proteine).

  2. Results corroborate the recent in vitro and murine data that suggest a close functional interaction between ADAMTS3 and CCBE1 (zeige CCBE1 Proteine) in triggering VEGFR3 (zeige FLT4 Proteine) signaling, a cornerstone for the differentiation and function of lymphatic endothelial cells.

  3. Findings suggest that these MMP16 (zeige MMP16 Proteine) rs10090371, ADAMTS3 rs788935, TLL2 (zeige TLL2 Proteine) rs10882807 and MMP9 (zeige MMP9 Proteine) rs3918251 may be promising prognostic biomarkers for cutaneous melanoma specific survival (CMSS).

  4. The pregnancy loss rate seems to be affected by both ADAMTS-3 and ADAMTS-16.

  5. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. [review]

  6. ADAMTS-2 (zeige ADAMTS4 Proteine), -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI (zeige CFD Proteine) compared those associated with stable angina.

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 3 (ADAMTS3) Interaktionspartner

  1. ADAMTS-3 was identified as the protease that cleaves and inactivates Reelin in the cerebral cortex and hippocampus. ADAMTS-3 was expressed in the excitatory neurons of the embryonic and postnatal cerebral cortex and hippocampus.

  2. an ADAMTS3 knockout mouse (Adamts3(-/-)) model was created to determine in vivo the actual functions of ADAMTS3.

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 3 (ADAMTS3) Protein Überblick

Protein Überblick

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.

Genbezeichner und Symbole assoziert mit ADAMTS3

  • ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3)
  • ADAM metallopeptidase with thrombospondin type 1, motif 3 (Adamts3)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 (Adamts3)
  • ADAM metallopeptidase with thrombospondin type 1 motif 3 (Adamts3)
  • 1100001H14Rik Protein
  • 6330442E02Rik Protein
  • ADAMTS-4 Protein

Bezeichner auf Proteinebene für ADAMTS3

A disintegrin and metalloproteinase with thrombospondin motifs 3 , ADAM-TS 3 , ADAM-TS3 , ADAMTS-3 , PC II-NP , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3 , procollagen II N-proteinase , procollagen II amino propeptide-processing enzyme , zinc metalloendopeptidase , ADAM metallopeptidase with thrombospondin type 1 motif, 3

GENE ID SPEZIES
9508 Homo sapiens
305253 Rattus norvegicus
330119 Mus musculus
100728969 Cavia porcellus
534082 Bos taurus
428760 Gallus gallus
100524818 Sus scrofa
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