anti-2',3'-Cyclic Nucleotide 3' phosphodiesterase (CNP) Antikörper

Human 2',3'-Cyclic Nucleotide 3' phosphodiesterase (CNP) Interaktionspartner

1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder.

2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway

3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication.

4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed.

5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane.

6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme.

7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival

8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome.

9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo

10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase

11. crystal structure of the catalytic fragment

12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia.

13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined.

14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population

15. MOBP and CNP protein in the white matter was not altered.

16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes.

17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population.

18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4.

19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population

20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia

Mouse (Murine) 2',3'-Cyclic Nucleotide 3' phosphodiesterase (CNP) Interaktionspartner

1. The results of this study suggested that with an appropriate reporter system Cnp activity can be used to define a proliferative subpopulation of NG2 cells committed to generate oligodendrocytes.

2. CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP).

3. Data show atomic-resolution details of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) catalytic domain active site.

4. These data provide detailed novel insight into the complex effects of natriuretic peptides and their receptors on electrical conduction in the heart.

5. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway

6. The data of this study reveal that CNPase is a critically important enzyme in the 2',3'-cAMP-adenosine pathway and participates in the production of adenosine, a protective neuromodulator.

7. Low levels of Cnp1 seen in major depressive disorder (MDD) may cause unsustainable and maladaptive molecular compensations. contributing to the disease pathophysiology.

8. The results indicate a role for the N-terminal domain of CNPase in mediating multiple molecular interactions and provide a starting point for detailed structure-function studies on CNPase and its N-terminal domain.

9. analysis of myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase active-site ligand binding and molecular conformation

10. The downregulation of CNPase expression in the brain may be a possible consequence of Mecp2 gene mutation

11. while OECs do not normally form myelin on olfactory nerve axons, their expression of CNPase is commensurate with their potential to form myelin when transplanted into injured peripheral nerve

12. The results of this study showed that CNP::EGFP mice were significantly more susceptible to CPZ-induced demyelination, as evaluated by MBP immunostaining, oligodendroglial progenitor cell recruitment and astroglial, microglial and nestin response.

13. Regulation of the Cnp gene, along with the relative amount of expressed Cnp enzyme, suggests that the immortalized cell lines containing them are representative of immature oligodendrocytes.

14. Cnp1, which encodes 2',3'-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly

15. We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice.

16. CNP is an important component of the cytoskeletal machinery that directs process outgrowth in Oligodendrocytes.

17. Cyclic nucleotide phosphodiesterase 1 (PDE1)is involved in the regulation of duodenal HCO(3)(-) secretion and the response to pde(2) is associated with both PDE1 and PDE3, while the response to nitric oxide is mainly modulated by PDE1.

18. We show that CNP is necessary for the formation of a normal inner tongue process of oligodendrocytes that myelinate small diameter axons. We also show that axonal degeneration in Cnp1 null mice is present very early in postnatal life.

Zebrafish 2',3'-Cyclic Nucleotide 3' phosphodiesterase (CNP) Interaktionspartner

1. mutant versions of zebrafish RICH proteins were generated to study the roles of the domains of the protein at biochemical and cellular levels.