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The results of this study suggested that with an appropriate reporter system Cnp activity can be used to define a proliferative subpopulation of NG2 cells committed to generate oligodendrocytes.
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CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP).
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Data show atomic-resolution details of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) catalytic domain active site.
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These data provide detailed novel insight into the complex effects of natriuretic peptides and their receptors on electrical conduction in the heart.
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kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway
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The data of this study reveal that CNPase is a critically important enzyme in the 2',3'-cAMP-adenosine pathway and participates in the production of adenosine, a protective neuromodulator.
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Low levels of Cnp1 seen in major depressive disorder (MDD) may cause unsustainable and maladaptive molecular compensations. contributing to the disease pathophysiology.
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The results indicate a role for the N-terminal domain of CNPase in mediating multiple molecular interactions and provide a starting point for detailed structure-function studies on CNPase and its N-terminal domain.
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analysis of myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase active-site ligand binding and molecular conformation
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The downregulation of CNPase expression in the brain may be a possible consequence of Mecp2 gene mutation
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while OECs do not normally form myelin on olfactory nerve axons, their expression of CNPase is commensurate with their potential to form myelin when transplanted into injured peripheral nerve
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The results of this study showed that CNP::EGFP mice were significantly more susceptible to CPZ-induced demyelination, as evaluated by MBP immunostaining, oligodendroglial progenitor cell recruitment and astroglial, microglial and nestin response.
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Regulation of the Cnp gene, along with the relative amount of expressed Cnp enzyme, suggests that the immortalized cell lines containing them are representative of immature oligodendrocytes.
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Cnp1, which encodes 2',3'-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly
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We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice.
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CNP is an important component of the cytoskeletal machinery that directs process outgrowth in Oligodendrocytes.
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Cyclic nucleotide phosphodiesterase 1 (PDE1)is involved in the regulation of duodenal HCO(3)(-) secretion and the response to pde(2) is associated with both PDE1 and PDE3, while the response to nitric oxide is mainly modulated by PDE1.
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We show that CNP is necessary for the formation of a normal inner tongue process of oligodendrocytes that myelinate small diameter axons. We also show that axonal degeneration in Cnp1 null mice is present very early in postnatal life.