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TRF2, a component of shelterin, binds to core histones to protect chromosome ends from inappropriate DNA damage response and loss of telomeric DNA. The N-terminal Gly/Arg-rich domain (GAR domain) of TRF2 directly binds to the globular domain of core histones.
TRF2 deficiency led to a 1,5-2 fold increase in the radiosensitivity of hMSC-telo1 (zeige ATM Proteine) cells through telomere destabilization.
DREEM imaging shows that in contrast to chromatin with DNA wrapping around histones, large TRF2-DNA complexes (with volumes larger than TRF2 tetramers) compact DNA inside TRF2 with portions of folded DNA appearing at the edge of these complexes.
observed that the expression of Sp1 (zeige PSG1 Proteine) is down-regulated in the TRF2(DeltaBDeltaM)-induced senescence, which was mediated by ATM (zeige ATM Proteine) and p38 MAPK (zeige MAPK14 Proteine)
Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.
These observations suggest that TRF2 is a good candidate for the attachment of telomeres to the nuclear envelope in somatic cells
Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 (zeige RABGEF1 Proteine) and TRF2
that a dimer of the shelterin subunit TRF2 wraps approximately 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain.
TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and formation of telomeric ultrafine anaphase bridges, ultimately leading to stochastic loss of telomeric sequences.
APB (zeige RNPEP Proteine) formation induced clustering of telomere repeats, telomere compaction and concomitant depletion of the shelterin protein TRF2 (also known as TERF2).
Overexpressing TRF2-S and silencing FMRP (zeige FMR1 Proteine) promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presynaptic terminals.
TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase (zeige TYRO3 Proteine) platelet-derived growth factor receptor beta (zeige PDGFRB Proteine) (PDGFRbeta).
role of TRF2 in skin homeostasis, is reported.
shelterin protein TIN2 (zeige TINF2 Proteine) can protect chromosome ends as a TRF2-tethered TIN2 (zeige TINF2 Proteine)/TPP1 (zeige TPP1 Proteine)/POT1 (zeige POT1 Proteine) complex that lacks a physical connection to TRF1 (zeige TERF1 Proteine)
We concluded that genomic instability resulting from loss of TRF2 expression provides biological advantages to the cancer stem cell population
Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1 (zeige TERF1 Proteine), Rap1 (zeige TERF2IP Proteine), or the POT1 (zeige POT1 Proteine) proteins (POT1a (zeige POT1 Proteine) and POT1b) had no effect on the frequency of t-loop occurrence.
TAF7L (zeige TAF7L Proteine) associates with TRF2 both in vitro and in testis, suggesting that TAF7L (zeige TAF7L Proteine) likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis.
Experiments in cells from knockout mice showed that uPAR (zeige PLAUR Proteine) controls the ubiquitin-proteasome system in VSMC & regulates doxorubicin-induced TRF2 ubiquitination and proteasomal degradation via this mechanism.
the molecular properties of TRF2 that are both necessary and sufficient to protect chromosome ends in mouse embryonic fibroblasts: the data support a two-step mechanism for TRF2-mediated end protection
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
telomeric repeat binding factor 2
, TTAGGG repeat-binding factor 2
, telomeric DNA-binding protein
, telomeric repeat binding protein 2
, telomeric repeat-binding factor 2
, TTAGGG-repeat binding factor 2 TRF2
, telomeric repeat binding factor a
, TTAGGG repeat binding factor 2