anti-SMAD3 (SMAD3) Antikörper

Bezeichnung:
anti-SMAD, Mothers Against DPP Homolog 3 Antikörper (SMAD3)
Auf www.antikoerper-online.de finden Sie aktuell 515 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Antikörper von 29 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD3 Kits (57) und SMAD3 Proteine (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 642 SMAD3 Produkte verfügbar.
Synonyme:
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3

Meistgesuchte Reaktivitäten zu anti-SMAD3 (SMAD3) Antikörper

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anti-Human SMAD3 Antikörper:

anti-Mouse (Murine) SMAD3 Antikörper:

anti-Rat (Rattus) SMAD3 Antikörper:

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Am meisten referenzierte anti-SMAD3 Antikörper

  1. Human Polyclonal SMAD3 Primary Antibody für EIA, IHC (p) - ABIN358226 : Venables, Bourgeois, Dalgliesh, Kister, Stevenin, Elliott: Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. in Human molecular genetics 2005 (PubMed)
    Zeige alle 5 Referenzen für 358226

  2. Human Polyclonal SMAD3 Primary Antibody für EIA, IHC (p) - ABIN358225 : Imoto, Sugiyama, Sekine, Matsuda: Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling. in FEBS letters 2005 (PubMed)
    Zeige alle 5 Referenzen für 358225

  3. Human Polyclonal SMAD3 Primary Antibody für ELISA, WB - ABIN1531634 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Zeige alle 2 Referenzen für 1531634

  4. Human Polyclonal SMAD3 Primary Antibody für IF (p), IHC (p) - ABIN746138 : Ghiabi, Jiang, Pasquier, Maleki, Abu-Kaoud, Halabi, Guerrouahen, Rafii, Rafii: Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. in Journal of translational medicine 2015 (PubMed)
    Zeige alle 2 Referenzen für 746138

  5. Human Polyclonal SMAD3 Primary Antibody für FACS, IF - ABIN653953 : Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013 (PubMed)
    Zeige alle 2 Referenzen für 653953

  6. Chicken Polyclonal SMAD3 Primary Antibody für EIA, IF - ABIN303328 : Carracedo, Lu, Popova, Jonsson, Eckes, Gullberg: The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation. in The Journal of biological chemistry 2010 (PubMed)
    Zeige alle 2 Referenzen für 303328

  7. Human Polyclonal SMAD3 Primary Antibody für IF (p), IHC (p) - ABIN756832 : Zhang, Ju, Zhang, Zhu, Nie, Xu, Lei et al.: Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4(+) T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 ... in Basic & clinical pharmacology & toxicology 2016 (PubMed)

  8. Human Polyclonal SMAD3 Primary Antibody für DB, IF - ABIN389656 : Cohen-Solal, Merrigan, Chan, Goydos, Chen, Foran, Liu, Lasfar, Reiss: Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition. in Pigment cell & melanoma research 2011 (PubMed)

  9. Dog (Canine) Polyclonal SMAD3 Primary Antibody für IHC, WB - ABIN2792537 : Cheng, Chang, Chao, Lee: Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. in Oncogene 2004 (PubMed)

Weitere Antikörper gegen SMAD3 Interaktionspartner

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Data suggest that Clock1a (zeige CLOCK Antikörper) coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a (zeige CLOCK Antikörper) alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a (zeige CLOCK Antikörper) activates Smad3a promoter via its E-box1 element. (Clock1a (zeige CLOCK Antikörper) = clock circadian regulator (zeige CLOCK Antikörper) a; Nodal = nodal modulator 1 (zeige NOMO1 Antikörper); Smad3a = SMAD (zeige SMAD1 Antikörper) family member 3a)

  2. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (zeige TGFB1 Antikörper) control of zebrafish spinal cord development

  3. Nodal signaling and mesendoderm induction depend on Smad2 (zeige SMAD2 Antikörper)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (zeige SMAD2 Antikörper)/3 signaling and embryonic patterning.

  4. although the role of Smad (zeige SMAD1 Antikörper) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (zeige TDP2 Antikörper) provides insight into a novel Smad (zeige SMAD1 Antikörper) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  5. Smad2 (zeige SMAD2 Antikörper)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. stablish PPM1A (zeige PPM1A Antikörper) as a novel repressor of the SMAD3 pathway in renal fibrosis

  2. Methylation in SMAD3 was selectively increased in asthmatic children of asthmatic mothers and was associated with childhood asthma risk

  3. a direct crosstalk between the STAT3 (zeige STAT3 Antikörper) and Smad3 signaling pathways that may contribute to tumor development and inflammation.

  4. It is reported here that TGF-beta (zeige TGFB1 Antikörper) directly regulates alternative splicing of cancer stem cell marker CD44 (zeige CD44 Antikörper) through a phosphorylated threonine179 of SMAD3-mediated interaction with RNA-binding protein (zeige PTBP1 Antikörper) PCBP1 (zeige PCBP1 Antikörper).

  5. Bcl-3 (zeige BCL3 Antikörper) knockdown enhanced the degradation of Smad3 but not Smad2 (zeige SMAD2 Antikörper) following TGFbeta (zeige TGFB1 Antikörper) treatment.

  6. miR (zeige MLXIP Antikörper)-206 and miR (zeige MLXIP Antikörper)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 (zeige TRIB2 Antikörper) promoter activity through p-Smad3.

  7. These studies support previously unrecognized, cooperative interaction between the CCN1 (zeige CCNA2 Antikörper) matricellular protein and canonical TGF-beta1 (zeige TGFB1 Antikörper)/SMAD3 signaling that promotes lung fibrosis.

  8. c-Abl (zeige ABL1 Antikörper) promotes TGF-beta (zeige TGFB1 Antikörper)-induced SKIP/Smad3 interaction.

  9. Substance P (zeige TAC1 Antikörper) can promote hepatic stem cell proliferation and induce HSC (zeige FUT1 Antikörper) activation via the TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 signaling pathway.

  10. High SMAD3 expression is associated with increased lung adenocarcinoma.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. E2a (zeige TCF3 Antikörper) is necessary to drive transcription of Smad2 (zeige SMAD2 Antikörper)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Activin A (zeige INHBA Antikörper) and overexpression of SMAD2 (zeige SMAD2 Antikörper)/3 significantly promoted expressions of porcine NANOG (zeige NANOG Antikörper) and OCT4 (zeige POU5F1 Antikörper),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Antikörper)/OCT4 (zeige POU5F1 Antikörper) expression.

  2. Smad3 regulate the activity and stability of myocardin (zeige MYOCD Antikörper)-related transcription factor during epithelial-myofibroblast transition

  3. SP1 (zeige SP1 Antikörper) and SMAD3 are required for high glucose-induced p21(WAF1 (zeige CDKN1A Antikörper)) gene transcription in LLC-PK1 (zeige PKLR Antikörper) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Data suggest that Gas5 suppresses Tgfb1 (zeige TGFB1 Antikörper)/Smad3 signaling in vascular smooth muscle cell differentiation from mesenchymal progenitor cells; Gas5 competitively binds Smad3 via multiple RNA Smad (zeige SMAD1 Antikörper)-binding elements. (Gas5 = growth arrest-specific 5 long non-coding RNA; Tgfb1 (zeige TGFB1 Antikörper) = transforming growth factor beta 1 (zeige TGFB1 Antikörper); Smad3 = MAD homolog 3 protein)

  2. point mutant that was unable to bind pSMAD3 proved ineffective. These findings indicate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferative actions of TGF-beta (zeige TGFB1 Antikörper).

  3. Soluble epoxide hydrolase (zeige EPHX2 Antikörper) inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38 (zeige CRK Antikörper)/Smad3 signaling pathway.

  4. A critical role for the Smad3-c-Jun (zeige JUN Antikörper) pathway in the regulation of Fstl1 (zeige FSTL1 Antikörper).

  5. Mirtazapine suppressed 5-HT (zeige DDC Antikörper)-mediated TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 and ERK1/2 (zeige MAPK1/3 Antikörper) signaling pathways as well as oxidative stress that contribute to the progression of liver fibrosis.

  6. These results suggest that Nedd9 (zeige NEDD9 Antikörper) is a Smad2 (zeige SMAD2 Antikörper)/3 target gene implicated in RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis.

  7. These results suggested that TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 signaling was activated during CCl4 (zeige CCL4 Antikörper)-induced acute liver injury in mice, and Smad3 overexpression aggravated acute liver injury by promoting inflammatory cells infiltration, inflammatory cytokines release and hepatocytes apoptosis.

  8. gonadotropin-releasing hormone receptor (zeige GNRHR Antikörper) mRNA levels were significantly elevated in knock-outs in both sexes. Interestingly, luteinizing hormone production was altered in a sex-specific fashion. Overall, our analyses demonstrate that SMAD3 is required for FSH (zeige BRD2 Antikörper) synthesis in vivo

  9. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

  10. hese studies revealed that Smad2 (zeige SMAD2 Antikörper) plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (zeige IHH Antikörper) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. the present work provides evidence supporting a functional role of SMAD2 (zeige SMAD2 Antikörper)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (zeige SMAD2 Antikörper)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2 (zeige SMAD2 Antikörper)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

SMAD3 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3) Antikörper
  • MAD homolog 3a (Drosophila) (smad3a) Antikörper
  • mothers against decapentaplegic homolog 3 (LOC100346303) Antikörper
  • SMAD family member 3 (smad3) Antikörper
  • SMAD family member 3 (Smad3) Antikörper
  • AU022421 Antikörper
  • HSPC193 Antikörper
  • HsT17436 Antikörper
  • JV15-2 Antikörper
  • LDS1C Antikörper
  • LDS3 Antikörper
  • mad3 Antikörper
  • Madh3 Antikörper
  • madh3-A Antikörper
  • madh3a Antikörper
  • Smad 3 Antikörper
  • smad3 Antikörper
  • wu:fa99e03 Antikörper
  • XenMLP Antikörper
  • Xmad3 Antikörper
  • XSmad3 Antikörper

Bezeichner auf Proteinebene für SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

GENE ID SPEZIES
100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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