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Human SMAD2 ELISA Kit für Sandwich ELISA - ABIN417849
Piotrowski, Kiszałkiewicz, Górski, Antczak, Górski, Pastuszak-Lewandoska, Migdalska-Sęk, Domańska-Senderowska, Nawrot, Czarnecka, Kurmanowska, Brzeziańska-Lasota: Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients. in BMC immunology 2015
Rat (Rattus) SMAD2 ELISA Kit für Sandwich ELISA - ABIN432538
Kabel, Abd Elmaaboud, Albarraq: Ameliorative potential of omega 3 fatty acids and HMG-CoA reductase inhibitors on experimentally-induced non-alcoholic steatohepatitis. in Prostaglandins, leukotrienes, and essential fatty acids 2015
The non-Smad (zeige SMAD1 ELISA Kits) JNK (zeige MAPK8 ELISA Kits) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (zeige SMAD1 ELISA Kits) pathway, and this nuclear movement is associated with Smad (zeige SMAD1 ELISA Kits) signal transduction toward the nucleus.
The results of this study found that Bptf and TGF-beta (zeige TGFB1 ELISA Kits)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A ELISA Kits) expression and hence neural posteriorization.
Smad2 and Eomesodermin (zeige EOMES ELISA Kits) a (Eomesa (zeige EOMES ELISA Kits)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES ELISA Kits) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
High Smad2 expression is associated with invasion and metastasis in pancreatic ductal adenocarcinoma.
Data indicate that miR (zeige MLXIP ELISA Kits)-206 inhibits neuropilin-1 (NRP1 (zeige NRP1 ELISA Kits)) and SMAD2 gene expression by directly binding to their 3'-UTRs.
Results show that members of the Activin (zeige Actbeta ELISA Kits) branch of the TGFbeta (zeige TGFB1 ELISA Kits) signaling pathway, namely Put and Smad2, are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
cells expressing mutant huntingtin (zeige HTT ELISA Kits) have a dysregulated transcriptional response to epidermal growth factor (zeige EGF ELISA Kits) stimulation
CRT (zeige SLC6A8 ELISA Kits) regulates TGF-beta1 (zeige TGFB1 ELISA Kits)-induced-EMT (zeige ITK ELISA Kits) through modulating Smad (zeige SMAD1 ELISA Kits) signaling
P311 (zeige C5orf13 ELISA Kits) is a novel TGFbeta1 (zeige TGFB1 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (zeige EGFR ELISA Kits) 2 (HER-2 (zeige ERBB2 ELISA Kits)) levels, were correlated well with TSP50 (zeige PRSS50 ELISA Kits)/p-Samd2/3 and TSP50 (zeige PRSS50 ELISA Kits)/p27 (zeige PAK2 ELISA Kits) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (zeige PRSS50 ELISA Kits)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
IL-17 (zeige IL17A ELISA Kits) can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 (zeige TGFB1 ELISA Kits) mediated Smad2/3 and ERK1/2 (zeige MAPK1/3 ELISA Kits) activation
a critical role for miR (zeige MLXIP ELISA Kits)-503-3p in induction of breast cancer EMT (zeige ITK ELISA Kits)
Grg4 occupancy at the Xnr1 (zeige NODAL ELISA Kits) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (zeige FOXH1 ELISA Kits) at the Xnr1 (zeige NODAL ELISA Kits) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (zeige TCF3 ELISA Kits) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (zeige GDF11 ELISA Kits) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (zeige INHBA ELISA Kits) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (zeige NANOG ELISA Kits) and OCT4 (zeige POU5F1 ELISA Kits),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG ELISA Kits)/OCT4 (zeige POU5F1 ELISA Kits) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (zeige TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 ELISA Kits)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 ELISA Kits).
Smad2- and Smad3 (zeige SMAD3 ELISA Kits)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (zeige TGFB1 ELISA Kits)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (zeige LRRC32 ELISA Kits) is involved in up-regulation of Tgfb3 (zeige TGFB3 ELISA Kits) and is essential for embryogenesis of palate; Garp (zeige LRRC32 ELISA Kits) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (zeige LRRC32 ELISA Kits) = glycoprotein A repetitions predominant (zeige LRRC32 ELISA Kits) protein; Tgfb3 (zeige TGFB3 ELISA Kits) = transforming growth factor beta 3 (zeige TGFB3 ELISA Kits))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (zeige TPM1 ELISA Kits), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (zeige TGFB1 ELISA Kits), Smad2, Smad3 (zeige SMAD3 ELISA Kits), Notch2 (zeige NOTCH2 ELISA Kits) and Notch3 (zeige NOTCH3 ELISA Kits) which, in turn, results in TGFbeta (zeige TGFB1 ELISA Kits) and Notch (zeige NOTCH1 ELISA Kits) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (zeige SMAD7 ELISA Kits) expression was increased after treatment with osthole.
These findings implicate TGF-beta (zeige TGFB1 ELISA Kits)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
selective inhibition of SMAD3 (zeige SMAD3 ELISA Kits) or CCT6A (zeige CCT6A ELISA Kits) efficiently suppresses TGF-beta (zeige TGFB1 ELISA Kits)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 ELISA Kits) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 ELISA Kits) for non-small-cell lung carcinoma.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2