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anti-Human HIPK2 Antikörper:
anti-Mouse (Murine) HIPK2 Antikörper:
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Cow (Bovine) Polyclonal HIPK2 Primary Antibody für IHC, WB - ABIN2779735
Steinmann, Schulte, Beck, Chachra, Bujnicki, Klempnauer: v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300. in Oncogene 2009
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Human Polyclonal HIPK2 Primary Antibody für EIA - ABIN358542
Guha, Chaerkady, Marimuthu, Patterson, Kashyap, Harsha, Sato, Bader, Lash, Minna, Pandey, Varmus: Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal HIPK2 Primary Antibody für ELISA, WB - ABIN565400
Esposito, Tornincasa, Chieffi, De Martino, Pierantoni, Fusco: High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene. in Cancer research 2010
Human Monoclonal HIPK2 Primary Antibody für ICC, IF - ABIN2668288
Isono, Nemoto, Li, Takada, Suzuki, Katsuki, Nakagawara, Koseki: Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. in Molecular and cellular biology 2006
Hipk2 promotes PP1c-mediated Dvl (zeige DVL2 Antikörper) dephosphorylation via its C-terminal domain and is essential Dvl (zeige DVL2 Antikörper) stability.
Cytoplasmic relocalization of HIPK2 induced by HMGA1 (zeige HMGA1 Antikörper) overexpression is a mechanism of inactivation of p53 (zeige TP53 Antikörper) apoptotic function.
Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (zeige GABPA Antikörper)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.
PARP1 (zeige PARP1 Antikörper) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.
In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (zeige FBXW7 Antikörper)-dependent proteasomal degradation of Notch1 (zeige NOTCH1 Antikörper) by phosphorylating its intracellular domain (Notch1 (zeige NOTCH1 Antikörper)-IC) within the Cdc4 (zeige FBXW7 Antikörper) phosphodegron motif.
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (zeige HDAC5 Antikörper) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (zeige HDAC5 Antikörper)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
These results suggest that the HIPK2-phospho-Ser271 CREB (zeige CREB1 Antikörper) axis is a new arsenic-responsive CREB (zeige CREB1 Antikörper) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (zeige CREB1 Antikörper) axis.
Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 (zeige SMAD3 Antikörper) signaling pathway.
Data show strong reduction of cell viability was induced in vitro and in vivo by the homeodomain interacting protein kinase 2 exon 8 spliced isoform (Hipk2-Deltae8)-specific siRNA, supporting a potential therapeutic application.
Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.
reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis
HIPK2 is ubiquitinated upon heat shock.
Phosphorylation of KLF3 (zeige KLF3 Antikörper) and CtBP2 (zeige CTBP2 Antikörper) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (zeige KLF3 Antikörper).
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (zeige AIRE Antikörper) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Hipk2 has an essential role in mouse white fat development
data identify Hipk2 as a novel regulator of C/EBPbeta (zeige CEBPB Antikörper) and implicate different protein kinases in the cooperation of p300 (zeige NOTCH1 Antikörper) with C/EBPbeta (zeige CEBPB Antikörper) and C/EBPalpha (zeige CEBPA Antikörper)
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
Hipk2 is a haploinsufficient tumor suppressor gene for mouse lymphoma development.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.
homeodomain interacting protein kinase 2
, serine/threonine protein kinase
, homeodomain-interacting protein kinase 2-like
, homeodomain-interacting protein kinase 2
, homeodomain-interacting protein kinase-2
, nuclear body-associated kinase 1
, sialophorin tail-associated nuclear serine/threonine-protein kinase
, Mx-interacting protein kinase PKM