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Human FOXO3 ELISA Kit für Sandwich ELISA - ABIN1000112
Leti, Malenica, Doshi, Courtright, Van Keuren-Jensen, Legendre, Still, Gerhard, DiStefano: High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. in Translational research : the journal of laboratory and clinical medicine 2015
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by modulating hypoxia-inducible factor activity via up-regulation of VHL (zeige VHL ELISA Kits), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer
in FOXO3-death-resistant cells no point mutations in the TP53 (zeige TP53 ELISA Kits)-DBD were found-in these cells FOXO3-TP53 (zeige TP53 ELISA Kits) complexes are formed and FOXO3-binding to the BIM (zeige BCL2L11 ELISA Kits)-promoter, but not the induction of the detoxifying protein SESN3 (zeige SESN3 ELISA Kits), were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (zeige ARHGEF16 ELISA Kits) cells
Taken together, these findings showed that TRIP6 (zeige TRIP6 ELISA Kits) plays an important role in promoting HCC (zeige FAM126A ELISA Kits) cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC (zeige FAM126A ELISA Kits).
NOTCH1 (zeige NOTCH1 ELISA Kits) inhibits activation of ATM (zeige ATM ELISA Kits) by impairing the formation of an ATM (zeige ATM ELISA Kits)-FOXO3a-KAT5 (zeige KAT5 ELISA Kits) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (zeige SOCS3 ELISA Kits), VAPA (zeige VAPA ELISA Kits), and COL5A2 (zeige COL5A2 ELISA Kits), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (zeige MYBL2 ELISA Kits), and 2 miRNAs hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-21-5p and hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC induces senescence through the AKT (zeige AKT1 ELISA Kits)-FoxO3a-ROS (zeige ROS1 ELISA Kits)-p53 (zeige TP53 ELISA Kits)-p21(Cip1/WAF1 (zeige CDKN1A ELISA Kits)) pathway in HCT116 and HEK293 cells.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (zeige TLR4 ELISA Kits) and C5aR (zeige C5AR1 ELISA Kits) crosstalk in dendritic cells induces a core regulatory network of RSK2 (zeige RPS6KA3 ELISA Kits), PI3Kbeta, SGK1 (zeige SGK1 ELISA Kits), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 (zeige FBXO32 ELISA Kits) and its transcription factor FOXO3A.
SIRT2 (zeige SIRT2 ELISA Kits) deacetylates Foxo3a, activates Bim (zeige BCL2L11 ELISA Kits), and induces apoptosis only in 1-methyl-4-phenylpyridinium-treated cells
MiR (zeige MLXIP ELISA Kits)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (zeige EOMES ELISA Kits) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (zeige HAND1 ELISA Kits) cell differentiation.
these results show that Cdk5 (zeige CDK5 ELISA Kits)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (zeige APP ELISA Kits) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (zeige IL6 ELISA Kits) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
These results indicate that myostatin (zeige MSTN ELISA Kits) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (zeige NR3C1 ELISA Kits) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (zeige AKT1 ELISA Kits) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (zeige CDK7 ELISA Kits) G (PKG (zeige PRKG1 ELISA Kits))-dependent downregulation of PGC-1 alpha (zeige PPARGC1A ELISA Kits) and the ROS (zeige ROS1 ELISA Kits) detoxification system in endothelial cells are mediated by the PI3K/Akt (zeige AKT1 ELISA Kits) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (zeige ROS1 ELISA Kits)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like