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Data suggest that NOX5 (zeige NOX5 ELISA Kits) expression in melanoma cells could contribute to cell proliferation due, in part, to the generation of high local concentrations of extracellular ROS (zeige ROS1 ELISA Kits) that modulate multiple pathways that regulate HIF-1alpha (zeige HIF1A ELISA Kits) and networks that signal through Akt (zeige AKT1 ELISA Kits)/GSK3beta (zeige GSK3b ELISA Kits)/p27(Kip1) .
SNHG6 acted as an oncogene (zeige RAB1A ELISA Kits) in gastric cancer cells through regulating miR (zeige MLXIP ELISA Kits)-101-3p/ZEB1 (zeige ZEB1 ELISA Kits) at a post-transcriptional level and silencing expression at a transcriptional level by recruiting enhancer of zeste homolog 2 (EZH2 (zeige EZH2 ELISA Kits)) to the promoter of p27 (zeige PAK2 ELISA Kits).
PCTAIRE1 (zeige CDK16 ELISA Kits) has a role in regulating p27 (zeige PAK2 ELISA Kits), c-Myc (zeige MYC ELISA Kits) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
Low P27KIP1 expression is associated with Non Small Cell Lung Cancer.
Results show that that Id2 was directly upregulated by BMP4 (zeige BMP4 ELISA Kits), resulting in the mediated expression of cell cycle regulatory protein of CDKN1B.
p27 (zeige PAK2 ELISA Kits) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (zeige RCHY1 ELISA Kits), are specifically involved in determining the clinical profiles of lung carcinomas.
In thyroid cancer cells, oncogene (zeige RAB1A ELISA Kits) activation prevented TGF-beta (zeige TGFB1 ELISA Kits)/SMAD (zeige SMAD1 ELISA Kits)-dependent p27 (zeige PAK2 ELISA Kits) repression, and CDK2 (zeige CDK2 ELISA Kits)/SMAD3 (zeige SMAD3 ELISA Kits) phosphorylation, leading to p65 (zeige GORASP1 ELISA Kits) NFkappaB (zeige NFKB1 ELISA Kits) upregulation which repressed BAX (zeige BAX ELISA Kits), induced cyclin D1 (zeige CCND1 ELISA Kits) and promoted TGF-beta (zeige TGFB1 ELISA Kits)-dependent growth.
PTEN loss and p27 (zeige PAK2 ELISA Kits) loss differ among morphologic patterns of prostate cancer.
abnormal levels of Skp2 and p27(KIP1) have probably been involved in the pathogenesis of ADH (zeige AVP ELISA Kits) and DCIS. Thus, Skp2 and p27(KIP1) may serve as important diagnosis markers.
Cip2a (zeige KIAA1524 ELISA Kits) markedly decreased the expression and nuclear localization of p27Kip1 and this is critical for the ability of Cip2a (zeige KIAA1524 ELISA Kits) to promote Triple-negative breast cancer progression.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
FoxO1a (zeige FOXO1 ELISA Kits) can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 (zeige PITX2 ELISA Kits) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 (zeige PITX2 ELISA Kits) causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (zeige PITX2 ELISA Kits) and p21.
Fbxo7 (zeige FBXO7 ELISA Kits)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (zeige CDK6 ELISA Kits) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (zeige FBXO7 ELISA Kits) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (zeige PGR ELISA Kits)-E2F (zeige E2F1 ELISA Kits) and p27-CDK (zeige CDK4 ELISA Kits) regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53 (zeige TP53 ELISA Kits), promotes ovarian tumor development from the benign adenomas of germ cell-deficient (zeige FANCL ELISA Kits) ovaries.
p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha (zeige TNF ELISA Kits)/nuclear factor-kappa b pathway. T
Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway.
These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1), GATA3 (zeige GATA3 ELISA Kits), and POU4F3 (zeige POU4F3 ELISA Kits) as additional therapeutic targets for ATOH1 (zeige ATOH1 ELISA Kits)-mediated auditory hair cells regeneration.
Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR (zeige MLXIP ELISA Kits)-24 and targeted by the transcription factors FOXO4 (zeige FOXO4 ELISA Kits) and AP4 (zeige REPIN1 ELISA Kits) in the peroxidasin (Pxdn (zeige PXDN ELISA Kits)) mutation-induced eye disorders, such as glaucoma.
These results suggest that fad24 may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level
The down-regulation of p27 and the activation of mTOR (zeige FRAP1 ELISA Kits) pathway may be involved in miR (zeige MLXIP ELISA Kits)-222-induced heart failure and autophagy inhibition.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
cyclin-dependent kinase inhibitor 1B
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27
, Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27/Kip1
, Cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor 1b, like