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These results provided evidence supporting the oncogenic potential of NFAT3 (zeige NFATC4 ELISA Kits) and suggested that CDK3 (zeige CDK3 ELISA Kits)-mediated phosphorylation of NFAT3 (zeige NFATC4 ELISA Kits) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (zeige MLXIP ELISA Kits)-150 downregulation in lung tumors correlates with higher CDK3 (zeige CDK3 ELISA Kits) levels. In addition, miR (zeige MLXIP ELISA Kits)-150 transfection experiments with cancer-derived cell lines reveal that miR (zeige MLXIP ELISA Kits)-150-mediated CDK3 (zeige CDK3 ELISA Kits) suppression directly induces growth inhibition.
High Cdk3 (zeige CDK3 ELISA Kits)-promoted epithelial-mesenchymal transition through activating AP-1 (zeige FOSB ELISA Kits) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (zeige MLXIP ELISA Kits)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) through inhibition of E2F2 transcription factor (E2F2 (zeige E2F2 ELISA Kits)), cyclin (zeige PCNA ELISA Kits)-dependent kinases CDK3 (zeige CDK3 ELISA Kits) and CDK6 (zeige CDK6 ELISA Kits).
Mir (zeige MLXIP ELISA Kits)-873 inhibits ESR1 (zeige ESR1 ELISA Kits) activity and cell growth via targeting CDK3 (zeige CDK3 ELISA Kits).
CDK3 (zeige CDK3 ELISA Kits) is associated with the progression of NPC (zeige NPC1 ELISA Kits), and may be a potential biomarker for prediction of the prognosis of patients with NPC (zeige NPC1 ELISA Kits).
The Walleye dermal sarcoma virus cyclin (zeige PCNA ELISA Kits) functions as a structural ortholog of cyclin C (zeige CCNC ELISA Kits) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (zeige CDK8 ELISA Kits) and Cdk3 (zeige CDK3 ELISA Kits).
NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin (zeige PCNA ELISA Kits)-dependent kinases
cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK (zeige EPHA3 ELISA Kits)-293 and a CHO (zeige COL11A1 ELISA Kits) cell lines.
data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation
Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 is involved in neuronal morphogenesis during development.
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
serine-threonine protein kinase NKIAMRE
, serine/threonine-protein kinase NKIAMRE
, serine/threonine kinase NKIATRE beta
, serine/threonine protein kinase NKIATRE
, cyclin-dependent kinase-like 3