CDK8 Proteine (CDK8)

Cyclin-Dependent Kinase 8 Proteine (CDK8)
Auf finden Sie aktuell 15 Cyclin-Dependent Kinase 8 (CDK8) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK8 Antikörper (91) und CDK8 Kits (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 133 CDK8 Produkte verfügbar.
K35, wu:fk95h11
alle Proteine anzeigen Gen GeneID UniProt
CDK8 1024 P49336
CDK8 264064 Q8R3L8
CDK8 447409 Q66KH9

Weitere Synonyme anzeigen

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Weitere Proteine zu CDK8 Interaktionspartnern

Human Cyclin-Dependent Kinase 8 (CDK8) Interaktionspartner

  1. These results identify CDK8 as a novel downstream mediator of estrogen receptors (ER) and suggest the utility of CDK8 inhibitors for ER-positive breast cancer therapy

  2. Our data suggest for the first time that CDK8 appears to contribute to the malignant mechanism of LSCC and may represent a significant prognostic marker for LSCC patients.

  3. On stimulation of TLR9 (zeige TLR9 Proteine), CDK8/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB (zeige NFKB1 Proteine) and C/EBPbeta (zeige CEBPB Proteine).

  4. Data suggest that, during neurogenesis, Mediator complex cyclin (zeige PCNA Proteine)-dependent kinases (CDK8, CDK19 (zeige CDK19 Proteine)) interact directly with PRC2 (polycomb (zeige CBX2 Proteine) repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2 (zeige EZH2 Proteine)), as well as SUZ12 (suppressor of zeste 12 homolog (zeige SUZ12 Proteine)).

  5. the expression of CDK8 and its interactive genes has a profound impact on the response to adjuvant therapy in breast cancer in accordance with the role of CDK8 in chemotherapy-induced tumor-supporting paracrine activities--{REVIEW}

  6. Data suggest that MED13, MED12, CDK8 and cyclin C (CycC (zeige CCNC Proteine)) comprise a four-subunit "kinase" module of the Mediator complex that functions as a major ingress of oncogenic and developmental signaling/gene expression in humans. [REVIEW]

  7. our data provided evidence that CDK-8 played a significant role in colon cancer hepatic metastasis by regulating the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signal pathway

  8. Collectively, our results implicate Ste12 and Tec1 as general and important contributors to the Cdk8, RNAPII-CTD regulatory circuitry as it relates to the maintenance of genome integrity

  9. miR (zeige MLXIP Proteine)-101 is a potent tumor repressor that directly represses CDK8 expression

  10. Mediator-associated kinases CDK8 and CDK19 (zeige CDK19 Proteine) restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (zeige RUNX1 Proteine)) cells

Zebrafish Cyclin-Dependent Kinase 8 (CDK8) Interaktionspartner

  1. Cloning, sequencing and developmental expression pattern of cyclin-dependent kinase 8.

Mouse (Murine) Cyclin-Dependent Kinase 8 (CDK8) Interaktionspartner

  1. our findings uncover a tumour suppressor function for CDK8 in vivo and suggest that the role of CDK8 activity in driving oncogenesis is context-specific.

  2. The Skp2-mH2A1 (zeige H2AFY Proteine)-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression.

  3. our results suggest that mTORC1 activation in NAFLD and insulin (zeige INS Proteine) resistance results in down-regulation of the CDK8-CycC (zeige CCNC Proteine) complex and elevation of lipogenic protein expression.

  4. Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8).

  5. CDK8 is a key regulator of STAT1 (zeige STAT1 Proteine) and antiviral responses.

  6. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

  7. This study illustrates a new gene-repressive mechanism of RIP140 (zeige NRIP1 Proteine) that can affect the transcription machinery by directly interacting with CDK8.

  8. knockdown of CDK8 in cells depleted of mH2A suppresses the proliferative advantage induced by mH2A loss

  9. Results suggest that transcriptional repression of genes critical for early-cell-fate determination underlies the requirement of Cdk8 in embryogenesis.

  10. As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9 (zeige CDK9 Proteine), which are components of transcriptional mediator and elongation complexes.

Caenorhabditis elegans (C. elegans) Cyclin-Dependent Kinase 8 (CDK8) Interaktionspartner

  1. The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation.

CDK8 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Alternative names and synonyms associated with CDK8

  • cyclin-dependent kinase 8 (LOC100353845)
  • cyclin-dependent kinase 8 (CDK8)
  • cyclin-dependent kinase 8 (cdk8)
  • cyclin-dependent kinase 8 (Cdk8)
  • cyclin-dependent kinase 8 (LOC100355706)
  • Protein CDK-8 (cdk-8)
  • K35 Protein
  • wu:fk95h11 Protein

Bezeichner auf Proteinebene für CDK8

cyclin-dependent kinase 8 , CDK8 protein kinase , cell division protein kinase 8 , mediator complex subunit CDK8 , mediator of RNA polymerase II transcription subunit CDK8 , protein kinase K35 , mediator complex subunit cdk8 , mediator of RNA polymerase II transcription subunit cdk8

100353845 Oryctolagus cuniculus
1024 Homo sapiens
373868 Danio rerio
447409 Xenopus laevis
428080 Gallus gallus
486035 Canis lupus familiaris
264064 Mus musculus
100524102 Sus scrofa
100355706 Oryctolagus cuniculus
172677 Caenorhabditis elegans
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