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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
high miR (zeige MLXIP Proteine)-154 expression suppressed glioblastoma cell migration, invasion, and EMT (zeige ITK Proteine) development through targeting Wnt5a.
Wnt5a suppressed osteoblastic differentiation through Ror2 (zeige ROR2 Proteine)/JNK (zeige MAPK8 Proteine) signaling in periodontal ligament stem cell-like cells.
Genetic blockade of autophagy indicated an unexpected feedback loop whereby knocking down the autophagy factor ATG5 (zeige ATG5 Proteine) in Wnt5A(high) cells decreased Wnt5A and increased beta-catenin (zeige CTNNB1 Proteine).
Low WNT5A expression is associated with prostate cancer.
WNT5A signaling regulates 15-PGDH (zeige HPGD Proteine) expression.
our study showed that, for the first time, different Wnt5a mRNA isoforms play distinct roles in colorectal cancer (CRC (zeige CALR Proteine)) and can be used as novel prognostic markers for CRC (zeige CALR Proteine) in the future.
High WNT5a expression is associated with osteoarthritis.
We conclude that in RS, WNT5A missense mutations have dominant neomorphic effects that interfere with the function of the wild-type protein.
RSPO2 (zeige RSPO2 Proteine) suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt (zeige WNT2 Proteine) pathway.
High expression of WNT5A is associated with squamous cell lung carcinoma.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (zeige WNT3A Proteine), acted across many cell diameters to orient Prickle3 (zeige PRICKLE3 Proteine)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (zeige ROR2 Proteine), which require Wnt5a/Ror2 (zeige ROR2 Proteine) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (zeige PCDH8 Proteine) signaling via RhoA (zeige RHOA Proteine) and Wnt5a/Ror2 (zeige ROR2 Proteine) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (zeige RSPO3 Proteine) binds syndecan 4 and that together they activate Wnt5a/PCP (zeige PRCP Proteine) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (zeige SDC4 Proteine) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (zeige PCDH8 Proteine) by XWnt-5A requires the receptor tyrosine kinase Ror2 (zeige ROR2 Proteine).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (zeige WNT2 Proteine)/JNK (zeige MAPK8 Proteine) signaling
WNT5A is a negative regulator of FSH (zeige BRD2 Proteine)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Wnt-5a activates NLK (Nemo-like kinase (zeige NLK Proteine)), which then phosphorylates a histone methyltransferase, SETDB1 (SET domain bifurcated 1 (zeige SETDB1 Proteine)), leading to the formation of a co-repressor complex that inactivates PPAR-gamma (zeige PPARG Proteine) function through histone H3 (zeige HIST3H3 Proteine)-K9 methylation.
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.
This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.
WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (zeige TGFB1 Proteine) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (zeige WNT5B Proteine) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (zeige FGF10 Proteine) and Ihh (zeige IHH Proteine).
findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5