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Human WNT5A ELISA Kit für Sandwich ELISA - ABIN481725
Schulte, Müller, Neumann, Oberhäuser, Faust, Güdelhöfer, Brandt, Krone, Laudes: Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. in PLoS ONE 2012
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Mouse (Murine) WNT5A ELISA Kit für Sandwich ELISA - ABIN837310
Dawes, Sugiyama, Lovicu, Harris, Shelley, McAvoy: Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. in Developmental biology 2014
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our study showed that, for the first time, different Wnt5a mRNA isoforms play distinct roles in colorectal cancer (CRC (zeige CALR ELISA Kits)) and can be used as novel prognostic markers for CRC (zeige CALR ELISA Kits) in the future.
High WNT5a expression is associated with osteoarthritis.
We conclude that in RS, WNT5A missense mutations have dominant neomorphic effects that interfere with the function of the wild-type protein.
RSPO2 (zeige RSPO2 ELISA Kits) suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt (zeige WNT2 ELISA Kits) pathway.
High expression of WNT5A is associated with squamous cell lung carcinoma.
Study shows that WNT5A stimulates dimerization of membrane-anchored FZD4 (zeige FZD4 ELISA Kits) CRDs and oligomerization of full-length FZD4 (zeige FZD4 ELISA Kits), which requires the integrity of CRD (zeige CRX ELISA Kits) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (zeige WNT2 ELISA Kits) binding through the CRDs and that the Wnt (zeige WNT2 ELISA Kits) palmitoleoyl group is important in promoting these interactions.
Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10, Wnt5a, alpha1 integrin (zeige ITGA1 ELISA Kits), and matrix metalloproteinase-3 (zeige MMP3 ELISA Kits) in GS/BMP-4 (zeige BMP4 ELISA Kits)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
Elevated WNT5A expression in obesity may function as a negative regulator of angiogenesis.NEW & NOTEWORTHY Wingless-related integration site 5a (WNT5A) negatively regulates adipose tissue angiogenesis via VEGF-A165b in human obesity.
Wnt5a as a master regulator of brain invasion, specifically tumor-promoting stem-like characteristics (TPC), and they provide a therapeutic rationale to target it in patients with glioblastoma.
inhibition of WNT-5A in vivo attenuated lung tissue destruction, improved lung function, and restored expression of beta-catenin (zeige CTNNB1 ELISA Kits)-driven target genes and alveolar epithelial cell markers in the elastase, as well as in cigarette smoke induced models of COPD (zeige ARCN1 ELISA Kits).
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (zeige WNT3A ELISA Kits), acted across many cell diameters to orient Prickle3 (zeige PRICKLE3 ELISA Kits)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (zeige ROR2 ELISA Kits), which require Wnt5a/Ror2 (zeige ROR2 ELISA Kits) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (zeige PCDH8 ELISA Kits) signaling via RhoA (zeige RHOA ELISA Kits) and Wnt5a/Ror2 (zeige ROR2 ELISA Kits) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (zeige RSPO3 ELISA Kits) binds syndecan 4 and that together they activate Wnt5a/PCP (zeige PRCP ELISA Kits) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (zeige SDC4 ELISA Kits) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (zeige PCDH8 ELISA Kits) by XWnt-5A requires the receptor tyrosine kinase Ror2 (zeige ROR2 ELISA Kits).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (zeige WNT2 ELISA Kits)/JNK (zeige MAPK8 ELISA Kits) signaling
WNT5A is a negative regulator of FSH (zeige BRD2 ELISA Kits)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.
This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.
WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (zeige TGFB1 ELISA Kits) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (zeige WNT5B ELISA Kits) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (zeige FGF10 ELISA Kits) and Ihh (zeige IHH ELISA Kits).
findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
Here we show that an evolutionarily conserved genomic region named AS3_9 comprises three TEs (zeige TES ELISA Kits) (AmnSINE1, X6b_DNA and MER117), inserted side-by-side, and functions as a distal enhancer for wnt5a expression during morphogenesis of the mammalian secondary palate.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5