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The authors conclude that inhibiting DNA methylation (zeige HELLS Proteine) by 5-Aza-dC mutual-exclusively regulates the lineage determination of adipogenesis and osteoblastogenesis by demethylating Wnt10a gene and upregulating its expression.
Wnt10a/beta-catenin (zeige CTNNB1 Proteine) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT (zeige TERT Proteine).
WNT10A plays an important role in the pathogenesis of IPF via TGF-beta (zeige TGFB1 Proteine) activation and it may also be a sensitive predictor for the onset of an AE-IPF.
Wnt10a regulates proliferation and apoptosis of embryonic palatal mesenchymal cells at least partially through the canonical Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.
Data indicate that that Wnt10a regulates Dspp (zeige DSPP Proteine) expression in mesenchymal cells.
Histone methyltransferase G9a (zeige EHMT2 Proteine) represses adipogenesis by inhibiting PPARgamma (zeige PPARG Proteine) expression and facilitating Wnt10a expression.
Mechanisms downstream of beta-catenin (zeige CTNNB1 Proteine) are required for Wnt6 (zeige WNT6 Proteine), Wnt10a and Wnt10b (zeige WNT10B Proteine) to influence differentiation of mesenchymal precursors.
WNT10A may be a novel angio/stromagenic growth factor
The development of maxillary canine, maxillary second molar and mandibular second molar was statistically significantly delayed in patients with WNT10A variants compared with patients without variants. The impact of WNT10A variants on dental development increases with presence of the nonsense c.(321C>A p.(C107*)) variant and the number of missing teeth
Results from genetic analysis revealed that all seven individuals were homozygous or compound heterozygous for WNT10A mutations suggesting that tooth agenesis and/or peg (zeige PAEP Proteine)-shaped crowns of primary mandibular incisors, severe oligodontia of permanent dentition as well as ectodermal symptoms of varying severity may be predictors of bi-allelic WNT10A mutations of importance for diagnosis, counselling and follow-up.
miR (zeige MLXIP Proteine)-378a-3p suppresses hepatic stellate cell activation, at least in part, via targeting of Wnt10a, supporting its potential utility as a novel therapeutic target for liver fibrosis.
risk of hypodontia may be related to the WNT10A polymorphism. Our results also confirm the importance of the Wnt (zeige WNT2 Proteine) pathway in tooth development.
WNT10A promotes the proliferation of DPCs and negatively regulates their odontoblastic differentiation.
WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness
p.Arg113Cys, p.Phe228Ile, newly identified p.Arg171Leu may represent aetiological mutations underlying MLIA w/associated dental anomalies, implicating coding variants in WNT10A gene
this study demonstrated that common variations in WNT10A have pleiotropic effects on the morphology of ectodermal appendages.
WNT10A may induce kidney fibrosis and associate with kidney dysfunction in acute interstitial nephritis.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
wingless-type MMTV integration site family, member 10A
, Wnt signaling ligand
, Wnt10a protein
, hypothetical protein
, WNT10A protein
, protein Wnt-10a-like
, protein Wnt-10a
, wingless related MMTV integration site 10a